Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants

Cpf1s, the RNA-guided nucleases of the class II clustered regularly interspaced short palindromic repeats system require a short motive called protospacer adjacent motif (PAM) to be present next to the targeted sequence for their activity. The TTTV PAM sequence of As- and LbCpf1 nucleases is relativ...

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Detalles Bibliográficos
Autores principales: Tóth, Eszter, Czene, Bernadett C, Kulcsár, Péter I, Krausz, Sarah L, Tálas, András, Nyeste, Antal, Varga, Éva, Huszár, Krisztina, Weinhardt, Nóra, Ligeti, Zoltán, Borsy, Adrienn É, Fodor, Elfrieda, Welker, Ervin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212782/
https://www.ncbi.nlm.nih.gov/pubmed/30239882
http://dx.doi.org/10.1093/nar/gky815

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