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Engineering a responsive DNA triple helix into an octahedral DNA nanostructure for a reversible opening/closing switching mechanism: a computational and experimental integrated study

We propose an experimental and simulative approach to study the effect of integrating a DNA functional device into a large-sized DNA nanostructure. We selected, as a test bed, a well-known and characterized pH-dependent clamp-switch, based on a parallel DNA triple helix, to be integrated into a trun...

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Detalles Bibliográficos
Autores principales:	Ottaviani, Alessio, Iacovelli, Federico, Idili, Andrea, Falconi, Mattia, Ricci, Francesco, Desideri, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212788/ https://www.ncbi.nlm.nih.gov/pubmed/30247614 http://dx.doi.org/10.1093/nar/gky857

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