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A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression

DNA damaging agents cause a variety of lesions, of which DNA double-strand breaks (DSBs) are the most genotoxic. Unbiased approaches aimed at investigating the relationship between the number of DSBs and outcome of the DNA damage response have been challenging due to the random nature in which damag...

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Detalles Bibliográficos
Autores principales:	van den Berg, Jeroen, G. Manjón, Anna, Kielbassa, Karoline, Feringa, Femke M, Freire, Raimundo, Medema, René H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212793/ https://www.ncbi.nlm.nih.gov/pubmed/30184135 http://dx.doi.org/10.1093/nar/gky786

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