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Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription

The RING finger protein TRAIP protects genome integrity and its mutation causes Seckel syndrome. TRAIP encodes a nucleolar protein that migrates to UV-induced DNA lesions via a direct interaction with the DNA replication clamp PCNA. Thus far, mechanistically how UV mobilizes TRAIP from the nucleoli...

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Detalles Bibliográficos
Autores principales:	Chen, Yangzi, Li, Junshi, Cao, Fakun, Lam, Jason, Cheng, Clooney CY, Yu, Cheng-han, Huen, Michael SY
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212796/ https://www.ncbi.nlm.nih.gov/pubmed/30165463 http://dx.doi.org/10.1093/nar/gky775

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