Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome

Misincorporation of uracil or spontaneous cytidine deamination is a common mutagenic insult to DNA. Herpesviruses encode a viral uracil-DNA glycosylase (vUNG) and a viral dUTPase (vDUT), each with enzymatic and nonenzymatic functions. However, the coordinated roles of these enzymatic activities in g...

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Detalles Bibliográficos
Autores principales: Dong, Qiwen, Smith, Kyle R., Oldenburg, Darby G., Shapiro, Maxwell, Schutt, William R., Malik, Laraib, Plummer, Joshua B., Mu, Yunxiang, MacCarthy, Thomas, White, Douglas W., McBride, Kevin M., Krug, Laurie T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212821/
https://www.ncbi.nlm.nih.gov/pubmed/30377280
http://dx.doi.org/10.1128/mBio.01831-18

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