Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris

Balamuthia mandrillaris is a pathogenic free-living amoeba that causes a rare but almost always fatal infection of the central nervous system called granulomatous amoebic encephalitis (GAE). Two distinct forms of B. mandrillaris—a proliferative trophozoite form and a nonproliferative cyst form, whic...

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Detalles Bibliográficos
Autores principales: Laurie, Matthew T., White, Corin V., Retallack, Hanna, Wu, Wesley, Moser, Matthew S., Sakanari, Judy A., Ang, Kenny, Wilson, Christopher, Arkin, Michelle R., DeRisi, Joseph L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212833/
https://www.ncbi.nlm.nih.gov/pubmed/30377287
http://dx.doi.org/10.1128/mBio.02051-18

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