Cargando…

A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding

Recently, Type III-A CRISPR-Cas systems were found to catalyze the synthesis of cyclic oligoadenylates (cOAs), a second messenger that specifically activates Csm6, a Cas accessory RNase and confers antiviral defense in bacteria. To test if III-B CRISPR-Cas systems could mediate a similar CRISPR sign...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Wenyuan, Stella, Stefano, Zhang, Yan, Guo, Tong, Sulek, Karolina, Peng-Lundgren, Li, Montoya, Guillermo, She, Qunxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212834/ https://www.ncbi.nlm.nih.gov/pubmed/30239876 http://dx.doi.org/10.1093/nar/gky844

Ejemplares similares

Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases
por: Molina, Rafael, et al.
Publicado: (2022)

Cyclic oligoadenylate signalling mediates Mycobacterium tuberculosis CRISPR defence
por: Grüschow, Sabine, et al.
Publicado: (2019)

Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR–Cas system by binding to target RNA and crRNA
por: Li, Yingjun, et al.
Publicado: (2017)

Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail
por: Han, Wenyuan, et al.
Publicado: (2017)

A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction
por: Han, Wenyuan, et al.
Publicado: (2017)

A type III-A CRISPR–Cas system mediates co-transcriptional DNA cleavage at the transcriptional bubbles in close proximity to active effectors
por: Lin, Jinzhong, et al.
Publicado: (2021)

Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2′,5′-oligoadenylate synthetase from prostate cancer cells
por: Molinaro, Ross J., et al.
Publicado: (2006)

Cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase-η
por: Genna, Vito, et al.
Publicado: (2016)

Structure and mechanism of the type I-G CRISPR effector
por: Shangguan, Qilin, et al.
Publicado: (2022)

Experimental demonstration of operon formation catalyzed by insertion sequence
por: Kanai, Yuki, et al.
Publicado: (2022)

Critical role of DNA intercalation in enzyme-catalyzed nucleotide flipping
por: Hendershot, Jenna M., et al.
Publicado: (2014)

PCNA and XPF cooperate to distort DNA substrates
por: Hutton, Richard D., et al.
Publicado: (2010)

Duplex strand joining reactions catalyzed by vaccinia virus DNA polymerase
por: Hamilton, Michael D., et al.
Publicado: (2007)

Nonfilament-forming RecA dimer catalyzes homologous joint formation
por: Shinohara, Takeshi, et al.
Publicado: (2018)

High fidelity of RecA-catalyzed recombination: a watchdog of genetic diversity
por: Sagi, Dror, et al.
Publicado: (2006)

Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids
por: Adelfinskaya, O., et al.
Publicado: (2007)

Genome-wide screening reveals metabolic regulation of stop-codon readthrough by cyclic AMP
por: Lyu, Zhihui, et al.
Publicado: (2023)

Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase
por: Brown, Jessica A., et al.
Publicado: (2008)

Mechanistic consequences of temperature on DNA polymerization catalyzed by a Y-family DNA polymerase
por: Fiala, Kevin A., et al.
Publicado: (2008)

DNA polymerase proofreading: active site switching catalyzed by the bacteriophage T4 DNA polymerase
por: Fidalgo da Silva, Elizabeth, et al.
Publicado: (2007)

Mechanism of RNA 2′,3′-cyclic phosphate end healing by T4 polynucleotide kinase–phosphatase
por: Das, Ushati, et al.
Publicado: (2013)

An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation
por: Friedt, Jenna, et al.
Publicado: (2014)

Controlling tetramer formation, subunit rotation and DNA ligation during Hin-catalyzed DNA inversion
por: Chang, Yong, et al.
Publicado: (2015)

Kinetics of the CRISPR-Cas9 effector complex assembly and the role of 3′-terminal segment of guide RNA
por: Mekler, Vladimir, et al.
Publicado: (2016)

Structural basis for the evolution of cyclic phosphodiesterase activity in the U6 snRNA exoribonuclease Usb1
por: Nomura, Yuichiro, et al.
Publicado: (2020)

The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence
por: Zhu, Wenlong, et al.
Publicado: (2021)

Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition
por: Lu, Catherine P., et al.
Publicado: (2008)

Archaeal RNA ligase is a homodimeric protein that catalyzes intramolecular ligation of single-stranded RNA and DNA
por: Torchia, Christopher, et al.
Publicado: (2008)

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP
por: Jemth, Ann-Sofie, et al.
Publicado: (2018)

Characterization of the 2′,3′ cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage λ phosphatase
por: Keppetipola, Niroshika, et al.
Publicado: (2007)

VpsR and cyclic di-GMP together drive transcription initiation to activate biofilm formation in Vibrio cholerae
por: Hsieh, Meng-Lun, et al.
Publicado: (2018)

Quantitative analysis of the efficiency and mutagenic spectra of abasic lesion bypass catalyzed by human Y-family DNA polymerases
por: Sherrer, Shanen M., et al.
Publicado: (2011)

Formation of m(2)G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14
por: Menezes, Sheena, et al.
Publicado: (2011)

DNA gyrase with a single catalytic tyrosine can catalyze DNA supercoiling by a nicking-closing mechanism
por: Gubaev, Airat, et al.
Publicado: (2016)

Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa
por: Jaroensuk, Juthamas, et al.
Publicado: (2016)

Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes
por: Vlot, Marnix, et al.
Publicado: (2018)

Significant contribution of the 3′→5′ exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ϵ
por: Zahurancik, Walter J., et al.
Publicado: (2014)

Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13
por: Lee, Na-Ra, et al.
Publicado: (2010)

mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5
por: Mock, Ulrike, et al.
Publicado: (2015)

Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions
por: Moukadiri, Ismaïl, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_0ebptta52mjj65rsj5cjk5bo97