Misfolding of a DNAzyme for ultrahigh sodium selectivity over potassium

Herein, the excellent Na(+) selectivity of a few RNA-cleaving DNAzymes was exploited, where Na(+) can be around 3000-fold more effective than K(+) for promoting catalysis. By using a double mutant based on the Ce13d DNAzyme, and by lowering the temperature, increased 2-aminopurine (2AP) fluorescence...

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Detalles Bibliográficos
Autores principales: He, Yanping, Chen, Da, Huang, Po-Jung Jimmy, Zhou, Yibo, Ma, Lingzi, Xu, Kexin, Yang, Ronghua, Liu, Juewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212836/
https://www.ncbi.nlm.nih.gov/pubmed/30215808
http://dx.doi.org/10.1093/nar/gky807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212836/
https://www.ncbi.nlm.nih.gov/pubmed/30215808
http://dx.doi.org/10.1093/nar/gky807

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