Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions

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The spatiotemporal program of metazoan DNA replication is regulated during development and altered in cancers. We have generated novel OK-seq, Repli-seq and RNA-seq data to compare the DNA replication and gene expression programs of twelve cancer and non-cancer human cell types. Changes in replicati...

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Detalles Bibliográficos
Autores principales: Wu, Xia, Kabalane, Hadi, Kahli, Malik, Petryk, Nataliya, Laperrousaz, Bastien, Jaszczyszyn, Yan, Drillon, Guenola, Nicolini, Frank-Emmanuel, Perot, Gaëlle, Robert, Aude, Fund, Cédric, Chibon, Frédéric, Xia, Ruohong, Wiels, Joëlle, Argoul, Françoise, Maguer-Satta, Véronique, Arneodo, Alain, Audit, Benjamin, Hyrien, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212843/
https://www.ncbi.nlm.nih.gov/pubmed/30189101
http://dx.doi.org/10.1093/nar/gky797
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