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Renoprotective Effects of Antroquinonol in Rats with N(ω)-Nitro-l-Arginine Methyl Ester-Induced Hypertension

Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day N(ω)...

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Autores principales: Chen, Jiun-Rong, Ko, Jung, Yeh, Wan-Ju, Huang, Wen-Chih, Yang, Hsin-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212859/
https://www.ncbi.nlm.nih.gov/pubmed/30336562
http://dx.doi.org/10.3390/nu10101521
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author Chen, Jiun-Rong
Ko, Jung
Yeh, Wan-Ju
Huang, Wen-Chih
Yang, Hsin-Yi
author_facet Chen, Jiun-Rong
Ko, Jung
Yeh, Wan-Ju
Huang, Wen-Chih
Yang, Hsin-Yi
author_sort Chen, Jiun-Rong
collection PubMed
description Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day N(ω)-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. During the experimental period, antroquinonol reduced the elevation of systolic and diastolic blood pressure. At the end of the study, we found that the antroquinonol groups had lower serum creatinine, renal endothelin-1, angiotensin II, and malondialdehyde levels and arteriole thickening. We found that the 40 mg/kg/day antroquinonol group had lower renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activities, greater nuclear factor erythroid-2, and heme oxygenase-1 expressions. Moreover, we also found that antroquinonol decreased proinflammatory cytokine concentrations in the kidney by modulating the nuclear factor-κB pathway. These results suggest that antroquinonol may ameliorate hypertension and improve renal function by reducing oxidative stress and inflammation in rats with endothelial dysfunction.
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spelling pubmed-62128592018-11-06 Renoprotective Effects of Antroquinonol in Rats with N(ω)-Nitro-l-Arginine Methyl Ester-Induced Hypertension Chen, Jiun-Rong Ko, Jung Yeh, Wan-Ju Huang, Wen-Chih Yang, Hsin-Yi Nutrients Article Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day N(ω)-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. During the experimental period, antroquinonol reduced the elevation of systolic and diastolic blood pressure. At the end of the study, we found that the antroquinonol groups had lower serum creatinine, renal endothelin-1, angiotensin II, and malondialdehyde levels and arteriole thickening. We found that the 40 mg/kg/day antroquinonol group had lower renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activities, greater nuclear factor erythroid-2, and heme oxygenase-1 expressions. Moreover, we also found that antroquinonol decreased proinflammatory cytokine concentrations in the kidney by modulating the nuclear factor-κB pathway. These results suggest that antroquinonol may ameliorate hypertension and improve renal function by reducing oxidative stress and inflammation in rats with endothelial dysfunction. MDPI 2018-10-17 /pmc/articles/PMC6212859/ /pubmed/30336562 http://dx.doi.org/10.3390/nu10101521 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Jiun-Rong
Ko, Jung
Yeh, Wan-Ju
Huang, Wen-Chih
Yang, Hsin-Yi
Renoprotective Effects of Antroquinonol in Rats with N(ω)-Nitro-l-Arginine Methyl Ester-Induced Hypertension
title Renoprotective Effects of Antroquinonol in Rats with N(ω)-Nitro-l-Arginine Methyl Ester-Induced Hypertension
title_full Renoprotective Effects of Antroquinonol in Rats with N(ω)-Nitro-l-Arginine Methyl Ester-Induced Hypertension
title_fullStr Renoprotective Effects of Antroquinonol in Rats with N(ω)-Nitro-l-Arginine Methyl Ester-Induced Hypertension
title_full_unstemmed Renoprotective Effects of Antroquinonol in Rats with N(ω)-Nitro-l-Arginine Methyl Ester-Induced Hypertension
title_short Renoprotective Effects of Antroquinonol in Rats with N(ω)-Nitro-l-Arginine Methyl Ester-Induced Hypertension
title_sort renoprotective effects of antroquinonol in rats with n(ω)-nitro-l-arginine methyl ester-induced hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212859/
https://www.ncbi.nlm.nih.gov/pubmed/30336562
http://dx.doi.org/10.3390/nu10101521
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