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Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients
Marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients (RTRs). Recommendations to increase marine-derived n-3 PUFAs by increasing fish intake may have a drawback in concomitant stimulation of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212909/ https://www.ncbi.nlm.nih.gov/pubmed/30282924 http://dx.doi.org/10.3390/nu10101419 |
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author | Sotomayor, Camilo G. Gomes-Neto, António W. Gans, Rijk O. B. de Borst, Martin H. Berger, Stefan P. Rodrigo, Ramón Navis, Gerjan J. Touw, Daan J. Bakker, Stephan J. L. |
author_facet | Sotomayor, Camilo G. Gomes-Neto, António W. Gans, Rijk O. B. de Borst, Martin H. Berger, Stefan P. Rodrigo, Ramón Navis, Gerjan J. Touw, Daan J. Bakker, Stephan J. L. |
author_sort | Sotomayor, Camilo G. |
collection | PubMed |
description | Marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients (RTRs). Recommendations to increase marine-derived n-3 PUFAs by increasing fish intake may have a drawback in concomitant stimulation of mercury intake, which could lead to higher circulating mercury concentrations and mitigation of otherwise beneficial effects of n-3 PUFAs. We aimed to monitor circulating mercury concentrations, and to prospectively evaluate whether it counteracts the potential association between fish intake and cardiovascular and all-cause mortality in a cohort of RTRs (n = 604, 53 ± 13 years-old, 57% men) with long-term follow-up (median of 5.4 years; 121 deaths). Circulating mercury concentration (median 0.30 (IQR 0.14–0.63) µg/L) positively associated with fish intake (std. β = 0.21, p < 0.001). Multivariable-adjusted Cox-proportional hazards regression analyses showed that prior to, and after additional adjustment for circulating mercury concentrations, fish intake was inversely associated with both cardiovascular (HR 0.75, 95% CI 0.58–0.96; and, HR 0.75, 95% CI 0.58–0.97, respectively) and all-cause mortality (HR 0.84, 95% CI 0.72–0.97; and, HR 0.86, 95% CI 0.74–0.99, respectively). Secondary analyses accounting for marine-derived n-3 PUFAs intake revealed associations of similar magnitude. In conclusion, we found no evidence of a counteracting effect conferred by circulating mercury concentrations on the associations between fish and marine-derived n-3 PUFAs intake and the risks of cardiovascular and all-cause mortality in RTRs. |
format | Online Article Text |
id | pubmed-6212909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62129092018-11-06 Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients Sotomayor, Camilo G. Gomes-Neto, António W. Gans, Rijk O. B. de Borst, Martin H. Berger, Stefan P. Rodrigo, Ramón Navis, Gerjan J. Touw, Daan J. Bakker, Stephan J. L. Nutrients Article Marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients (RTRs). Recommendations to increase marine-derived n-3 PUFAs by increasing fish intake may have a drawback in concomitant stimulation of mercury intake, which could lead to higher circulating mercury concentrations and mitigation of otherwise beneficial effects of n-3 PUFAs. We aimed to monitor circulating mercury concentrations, and to prospectively evaluate whether it counteracts the potential association between fish intake and cardiovascular and all-cause mortality in a cohort of RTRs (n = 604, 53 ± 13 years-old, 57% men) with long-term follow-up (median of 5.4 years; 121 deaths). Circulating mercury concentration (median 0.30 (IQR 0.14–0.63) µg/L) positively associated with fish intake (std. β = 0.21, p < 0.001). Multivariable-adjusted Cox-proportional hazards regression analyses showed that prior to, and after additional adjustment for circulating mercury concentrations, fish intake was inversely associated with both cardiovascular (HR 0.75, 95% CI 0.58–0.96; and, HR 0.75, 95% CI 0.58–0.97, respectively) and all-cause mortality (HR 0.84, 95% CI 0.72–0.97; and, HR 0.86, 95% CI 0.74–0.99, respectively). Secondary analyses accounting for marine-derived n-3 PUFAs intake revealed associations of similar magnitude. In conclusion, we found no evidence of a counteracting effect conferred by circulating mercury concentrations on the associations between fish and marine-derived n-3 PUFAs intake and the risks of cardiovascular and all-cause mortality in RTRs. MDPI 2018-10-03 /pmc/articles/PMC6212909/ /pubmed/30282924 http://dx.doi.org/10.3390/nu10101419 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sotomayor, Camilo G. Gomes-Neto, António W. Gans, Rijk O. B. de Borst, Martin H. Berger, Stefan P. Rodrigo, Ramón Navis, Gerjan J. Touw, Daan J. Bakker, Stephan J. L. Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients |
title | Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients |
title_full | Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients |
title_fullStr | Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients |
title_full_unstemmed | Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients |
title_short | Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients |
title_sort | fish intake, circulating mercury and mortality in renal transplant recipients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212909/ https://www.ncbi.nlm.nih.gov/pubmed/30282924 http://dx.doi.org/10.3390/nu10101419 |
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