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The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
AMPK (5’-adenosine monophosphate-activated protein kinase) is heavily involved in skeletal muscle metabolic control through its regulation of many downstream targets. Because of their effects on anabolic and catabolic cellular processes, AMPK plays an important role in the control of skeletal muscle...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212977/ https://www.ncbi.nlm.nih.gov/pubmed/30314396 http://dx.doi.org/10.3390/ijms19103125 |
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author | Thomson, David M. |
author_facet | Thomson, David M. |
author_sort | Thomson, David M. |
collection | PubMed |
description | AMPK (5’-adenosine monophosphate-activated protein kinase) is heavily involved in skeletal muscle metabolic control through its regulation of many downstream targets. Because of their effects on anabolic and catabolic cellular processes, AMPK plays an important role in the control of skeletal muscle development and growth. In this review, the effects of AMPK signaling, and those of its upstream activator, liver kinase B1 (LKB1), on skeletal muscle growth and atrophy are reviewed. The effect of AMPK activity on satellite cell-mediated muscle growth and regeneration after injury is also reviewed. Together, the current data indicate that AMPK does play an important role in regulating muscle mass and regeneration, with AMPKα1 playing a prominent role in stimulating anabolism and in regulating satellite cell dynamics during regeneration, and AMPKα2 playing a potentially more important role in regulating muscle degradation during atrophy. |
format | Online Article Text |
id | pubmed-6212977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62129772018-11-14 The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration Thomson, David M. Int J Mol Sci Review AMPK (5’-adenosine monophosphate-activated protein kinase) is heavily involved in skeletal muscle metabolic control through its regulation of many downstream targets. Because of their effects on anabolic and catabolic cellular processes, AMPK plays an important role in the control of skeletal muscle development and growth. In this review, the effects of AMPK signaling, and those of its upstream activator, liver kinase B1 (LKB1), on skeletal muscle growth and atrophy are reviewed. The effect of AMPK activity on satellite cell-mediated muscle growth and regeneration after injury is also reviewed. Together, the current data indicate that AMPK does play an important role in regulating muscle mass and regeneration, with AMPKα1 playing a prominent role in stimulating anabolism and in regulating satellite cell dynamics during regeneration, and AMPKα2 playing a potentially more important role in regulating muscle degradation during atrophy. MDPI 2018-10-11 /pmc/articles/PMC6212977/ /pubmed/30314396 http://dx.doi.org/10.3390/ijms19103125 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Thomson, David M. The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration |
title | The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration |
title_full | The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration |
title_fullStr | The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration |
title_full_unstemmed | The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration |
title_short | The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration |
title_sort | role of ampk in the regulation of skeletal muscle size, hypertrophy, and regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212977/ https://www.ncbi.nlm.nih.gov/pubmed/30314396 http://dx.doi.org/10.3390/ijms19103125 |
work_keys_str_mv | AT thomsondavidm theroleofampkintheregulationofskeletalmusclesizehypertrophyandregeneration AT thomsondavidm roleofampkintheregulationofskeletalmusclesizehypertrophyandregeneration |