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The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration

AMPK (5’-adenosine monophosphate-activated protein kinase) is heavily involved in skeletal muscle metabolic control through its regulation of many downstream targets. Because of their effects on anabolic and catabolic cellular processes, AMPK plays an important role in the control of skeletal muscle...

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Detalles Bibliográficos
Autor principal: Thomson, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212977/
https://www.ncbi.nlm.nih.gov/pubmed/30314396
http://dx.doi.org/10.3390/ijms19103125
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author Thomson, David M.
author_facet Thomson, David M.
author_sort Thomson, David M.
collection PubMed
description AMPK (5’-adenosine monophosphate-activated protein kinase) is heavily involved in skeletal muscle metabolic control through its regulation of many downstream targets. Because of their effects on anabolic and catabolic cellular processes, AMPK plays an important role in the control of skeletal muscle development and growth. In this review, the effects of AMPK signaling, and those of its upstream activator, liver kinase B1 (LKB1), on skeletal muscle growth and atrophy are reviewed. The effect of AMPK activity on satellite cell-mediated muscle growth and regeneration after injury is also reviewed. Together, the current data indicate that AMPK does play an important role in regulating muscle mass and regeneration, with AMPKα1 playing a prominent role in stimulating anabolism and in regulating satellite cell dynamics during regeneration, and AMPKα2 playing a potentially more important role in regulating muscle degradation during atrophy.
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spelling pubmed-62129772018-11-14 The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration Thomson, David M. Int J Mol Sci Review AMPK (5’-adenosine monophosphate-activated protein kinase) is heavily involved in skeletal muscle metabolic control through its regulation of many downstream targets. Because of their effects on anabolic and catabolic cellular processes, AMPK plays an important role in the control of skeletal muscle development and growth. In this review, the effects of AMPK signaling, and those of its upstream activator, liver kinase B1 (LKB1), on skeletal muscle growth and atrophy are reviewed. The effect of AMPK activity on satellite cell-mediated muscle growth and regeneration after injury is also reviewed. Together, the current data indicate that AMPK does play an important role in regulating muscle mass and regeneration, with AMPKα1 playing a prominent role in stimulating anabolism and in regulating satellite cell dynamics during regeneration, and AMPKα2 playing a potentially more important role in regulating muscle degradation during atrophy. MDPI 2018-10-11 /pmc/articles/PMC6212977/ /pubmed/30314396 http://dx.doi.org/10.3390/ijms19103125 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Thomson, David M.
The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
title The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
title_full The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
title_fullStr The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
title_full_unstemmed The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
title_short The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
title_sort role of ampk in the regulation of skeletal muscle size, hypertrophy, and regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212977/
https://www.ncbi.nlm.nih.gov/pubmed/30314396
http://dx.doi.org/10.3390/ijms19103125
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