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Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

(1) Background: The red seaweed Palmaria mollis (PM), which has a bacon-like taste, is increasingly being included in Western diets. In this study, we evaluate anti-obesity effects of PM using diet-induced obese (DIO) zebrafish and mice models. (2) Methods: We fed PM-containing feed to DIO-zebrafish...

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Autores principales: Nakayama, Hiroko, Shimada, Yasuhito, Zang, Liqing, Terasawa, Masahiro, Nishiura, Kaoru, Matsuda, Koichi, Toombs, Charles, Langdon, Chris, Nishimura, Norihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213011/
https://www.ncbi.nlm.nih.gov/pubmed/30279329
http://dx.doi.org/10.3390/nu10101401
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author Nakayama, Hiroko
Shimada, Yasuhito
Zang, Liqing
Terasawa, Masahiro
Nishiura, Kaoru
Matsuda, Koichi
Toombs, Charles
Langdon, Chris
Nishimura, Norihiro
author_facet Nakayama, Hiroko
Shimada, Yasuhito
Zang, Liqing
Terasawa, Masahiro
Nishiura, Kaoru
Matsuda, Koichi
Toombs, Charles
Langdon, Chris
Nishimura, Norihiro
author_sort Nakayama, Hiroko
collection PubMed
description (1) Background: The red seaweed Palmaria mollis (PM), which has a bacon-like taste, is increasingly being included in Western diets. In this study, we evaluate anti-obesity effects of PM using diet-induced obese (DIO) zebrafish and mice models. (2) Methods: We fed PM-containing feed to DIO-zebrafish and mice, and evaluated the anti-obesity effects We also analyzed gene expression changes in their liver and visceral adipose tissues (VAT). (3) Results: PM ameliorated several anti-obesity traits in both animals, including dyslipidaemia, hepatic steatosis, and visceral adiposity. In liver tissues of DIO-zebrafish and mice, PM upregulated gene expressions involved in peroxisome proliferator-activated receptor alpha (PPARA) pathways, and downregulated peroxisome proliferator-activated receptor gamma (PPARG) pathways, suggesting that the lipid-lowering effect of PM might be caused by activation of beta-oxidation and inhibition of lipogenesis. In VAT, PM downregulated genes involved in early and late adipocyte differentiation in zebrafish, but not in mice. (4) Conclusions: We have demonstrated that PM can prevent hepatic steatosis and visceral adiposity for the first time. Dietary supplementation of PM as a functional food may be suitable for obesity prevention and reduction in the prevalence of obesity-related diseases.
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spelling pubmed-62130112018-11-06 Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models Nakayama, Hiroko Shimada, Yasuhito Zang, Liqing Terasawa, Masahiro Nishiura, Kaoru Matsuda, Koichi Toombs, Charles Langdon, Chris Nishimura, Norihiro Nutrients Article (1) Background: The red seaweed Palmaria mollis (PM), which has a bacon-like taste, is increasingly being included in Western diets. In this study, we evaluate anti-obesity effects of PM using diet-induced obese (DIO) zebrafish and mice models. (2) Methods: We fed PM-containing feed to DIO-zebrafish and mice, and evaluated the anti-obesity effects We also analyzed gene expression changes in their liver and visceral adipose tissues (VAT). (3) Results: PM ameliorated several anti-obesity traits in both animals, including dyslipidaemia, hepatic steatosis, and visceral adiposity. In liver tissues of DIO-zebrafish and mice, PM upregulated gene expressions involved in peroxisome proliferator-activated receptor alpha (PPARA) pathways, and downregulated peroxisome proliferator-activated receptor gamma (PPARG) pathways, suggesting that the lipid-lowering effect of PM might be caused by activation of beta-oxidation and inhibition of lipogenesis. In VAT, PM downregulated genes involved in early and late adipocyte differentiation in zebrafish, but not in mice. (4) Conclusions: We have demonstrated that PM can prevent hepatic steatosis and visceral adiposity for the first time. Dietary supplementation of PM as a functional food may be suitable for obesity prevention and reduction in the prevalence of obesity-related diseases. MDPI 2018-10-02 /pmc/articles/PMC6213011/ /pubmed/30279329 http://dx.doi.org/10.3390/nu10101401 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nakayama, Hiroko
Shimada, Yasuhito
Zang, Liqing
Terasawa, Masahiro
Nishiura, Kaoru
Matsuda, Koichi
Toombs, Charles
Langdon, Chris
Nishimura, Norihiro
Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models
title Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models
title_full Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models
title_fullStr Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models
title_full_unstemmed Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models
title_short Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models
title_sort novel anti-obesity properties of palmaria mollis in zebrafish and mouse models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213011/
https://www.ncbi.nlm.nih.gov/pubmed/30279329
http://dx.doi.org/10.3390/nu10101401
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