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Association of Dietary Fatty Acids with Blood Lipids is Modified by Physical Activity in Adolescents: Results from the GINIplus and LISA Birth Cohort Studies

The role of consuming different types of fatty acids (FA) at the expense of carbohydrates (CHO), on the blood lipid profile of adolescents is largely unknown, as is the modulating effect of different levels of physical activity (PA). Children from the GINIplus and LISA birth cohorts, with complete d...

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Autores principales: Harris, Carla P., von Berg, Andrea, Berdel, Dietrich, Bauer, Carl-Peter, Schikowski, Tamara, Koletzko, Sibylle, Heinrich, Joachim, Schulz, Holger, Standl, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213167/
https://www.ncbi.nlm.nih.gov/pubmed/30257483
http://dx.doi.org/10.3390/nu10101372
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author Harris, Carla P.
von Berg, Andrea
Berdel, Dietrich
Bauer, Carl-Peter
Schikowski, Tamara
Koletzko, Sibylle
Heinrich, Joachim
Schulz, Holger
Standl, Marie
author_facet Harris, Carla P.
von Berg, Andrea
Berdel, Dietrich
Bauer, Carl-Peter
Schikowski, Tamara
Koletzko, Sibylle
Heinrich, Joachim
Schulz, Holger
Standl, Marie
author_sort Harris, Carla P.
collection PubMed
description The role of consuming different types of fatty acids (FA) at the expense of carbohydrates (CHO), on the blood lipid profile of adolescents is largely unknown, as is the modulating effect of different levels of physical activity (PA). Children from the GINIplus and LISA birth cohorts, with complete data on dietary FA (assessed by food-frequency questionnaires), objectively-measured PA (assessed by accelerometers) and blood lipids (lipoprotein cholesterol and triglycerides) at age 15 years, were included (N = 837). Sex-stratified associations between dietary FA and blood lipids were assessed by linear regression in substitution models which represented isocaloric replacements of CHO with saturated FA (SFA), monounsaturated FA (MUFA), n-3 polyunsaturated FA (PUFA) or n-6 PUFA. To assess the interactions with PA, analyses were then performed stratified by tertiles of different PA levels (sedentary, lifestyle, moderate-to-vigorous (MVPA)). Both sexes presented a significant inverse association between MUFA and triglycerides, and females a direct association between n-3 PUFA and high-density lipoprotein. Stratifying by PA tertiles, associations were mainly restricted to participants with the lowest levels of lifestyle PA, or the highest time spent sedentary. The effects of dietary FA on the lipid profile vary in an activity-specific manner, emphasizing possible synergistic roles of diet and PA.
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spelling pubmed-62131672018-11-06 Association of Dietary Fatty Acids with Blood Lipids is Modified by Physical Activity in Adolescents: Results from the GINIplus and LISA Birth Cohort Studies Harris, Carla P. von Berg, Andrea Berdel, Dietrich Bauer, Carl-Peter Schikowski, Tamara Koletzko, Sibylle Heinrich, Joachim Schulz, Holger Standl, Marie Nutrients Article The role of consuming different types of fatty acids (FA) at the expense of carbohydrates (CHO), on the blood lipid profile of adolescents is largely unknown, as is the modulating effect of different levels of physical activity (PA). Children from the GINIplus and LISA birth cohorts, with complete data on dietary FA (assessed by food-frequency questionnaires), objectively-measured PA (assessed by accelerometers) and blood lipids (lipoprotein cholesterol and triglycerides) at age 15 years, were included (N = 837). Sex-stratified associations between dietary FA and blood lipids were assessed by linear regression in substitution models which represented isocaloric replacements of CHO with saturated FA (SFA), monounsaturated FA (MUFA), n-3 polyunsaturated FA (PUFA) or n-6 PUFA. To assess the interactions with PA, analyses were then performed stratified by tertiles of different PA levels (sedentary, lifestyle, moderate-to-vigorous (MVPA)). Both sexes presented a significant inverse association between MUFA and triglycerides, and females a direct association between n-3 PUFA and high-density lipoprotein. Stratifying by PA tertiles, associations were mainly restricted to participants with the lowest levels of lifestyle PA, or the highest time spent sedentary. The effects of dietary FA on the lipid profile vary in an activity-specific manner, emphasizing possible synergistic roles of diet and PA. MDPI 2018-09-25 /pmc/articles/PMC6213167/ /pubmed/30257483 http://dx.doi.org/10.3390/nu10101372 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Harris, Carla P.
von Berg, Andrea
Berdel, Dietrich
Bauer, Carl-Peter
Schikowski, Tamara
Koletzko, Sibylle
Heinrich, Joachim
Schulz, Holger
Standl, Marie
Association of Dietary Fatty Acids with Blood Lipids is Modified by Physical Activity in Adolescents: Results from the GINIplus and LISA Birth Cohort Studies
title Association of Dietary Fatty Acids with Blood Lipids is Modified by Physical Activity in Adolescents: Results from the GINIplus and LISA Birth Cohort Studies
title_full Association of Dietary Fatty Acids with Blood Lipids is Modified by Physical Activity in Adolescents: Results from the GINIplus and LISA Birth Cohort Studies
title_fullStr Association of Dietary Fatty Acids with Blood Lipids is Modified by Physical Activity in Adolescents: Results from the GINIplus and LISA Birth Cohort Studies
title_full_unstemmed Association of Dietary Fatty Acids with Blood Lipids is Modified by Physical Activity in Adolescents: Results from the GINIplus and LISA Birth Cohort Studies
title_short Association of Dietary Fatty Acids with Blood Lipids is Modified by Physical Activity in Adolescents: Results from the GINIplus and LISA Birth Cohort Studies
title_sort association of dietary fatty acids with blood lipids is modified by physical activity in adolescents: results from the giniplus and lisa birth cohort studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213167/
https://www.ncbi.nlm.nih.gov/pubmed/30257483
http://dx.doi.org/10.3390/nu10101372
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