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Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review

Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA sta...

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Autores principales: Khor, Ban-Hock, Narayanan, Sreelakshmi Sankara, Chinna, Karuthan, Gafor, Abdul Halim Abdul, Daud, Zulfitri Azuan Mat, Khosla, Pramod, Sundram, Kalyana, Karupaiah, Tilakavati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213187/
https://www.ncbi.nlm.nih.gov/pubmed/30248953
http://dx.doi.org/10.3390/nu10101353
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author Khor, Ban-Hock
Narayanan, Sreelakshmi Sankara
Chinna, Karuthan
Gafor, Abdul Halim Abdul
Daud, Zulfitri Azuan Mat
Khosla, Pramod
Sundram, Kalyana
Karupaiah, Tilakavati
author_facet Khor, Ban-Hock
Narayanan, Sreelakshmi Sankara
Chinna, Karuthan
Gafor, Abdul Halim Abdul
Daud, Zulfitri Azuan Mat
Khosla, Pramod
Sundram, Kalyana
Karupaiah, Tilakavati
author_sort Khor, Ban-Hock
collection PubMed
description Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onwards, reporting FA profile in hemodialysis and peritoneal DP, were identified from PubMed, Embase, and the Cochrane library. Studies on pediatric, predialysis chronic kidney disease, acute kidney injury, and transplant patients were excluded. Moderate to high levels of n-3 polyunsaturated fatty acids (PUFA) were reported in Japan, Korea, Denmark, and Sweden. Compared to healthy adults, DP had lower proportions of n-3 and n-6 PUFA, but higher proportion of monounsaturated fatty acids. Two studies reported inverse associations between n-3 PUFAs and risks of sudden cardiac death, while one reported eicosapentaenoic acid + docosahexaenoic acid)/arachidonic acid ratio was inversely associated with cardiovascular events. The relationship between all-cause mortality and blood FA composition in DP remained inconclusive. The current evidence highlights a critical role for essential FA in nutritional management of DP.
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spelling pubmed-62131872018-11-06 Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review Khor, Ban-Hock Narayanan, Sreelakshmi Sankara Chinna, Karuthan Gafor, Abdul Halim Abdul Daud, Zulfitri Azuan Mat Khosla, Pramod Sundram, Kalyana Karupaiah, Tilakavati Nutrients Review Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onwards, reporting FA profile in hemodialysis and peritoneal DP, were identified from PubMed, Embase, and the Cochrane library. Studies on pediatric, predialysis chronic kidney disease, acute kidney injury, and transplant patients were excluded. Moderate to high levels of n-3 polyunsaturated fatty acids (PUFA) were reported in Japan, Korea, Denmark, and Sweden. Compared to healthy adults, DP had lower proportions of n-3 and n-6 PUFA, but higher proportion of monounsaturated fatty acids. Two studies reported inverse associations between n-3 PUFAs and risks of sudden cardiac death, while one reported eicosapentaenoic acid + docosahexaenoic acid)/arachidonic acid ratio was inversely associated with cardiovascular events. The relationship between all-cause mortality and blood FA composition in DP remained inconclusive. The current evidence highlights a critical role for essential FA in nutritional management of DP. MDPI 2018-09-21 /pmc/articles/PMC6213187/ /pubmed/30248953 http://dx.doi.org/10.3390/nu10101353 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khor, Ban-Hock
Narayanan, Sreelakshmi Sankara
Chinna, Karuthan
Gafor, Abdul Halim Abdul
Daud, Zulfitri Azuan Mat
Khosla, Pramod
Sundram, Kalyana
Karupaiah, Tilakavati
Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review
title Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review
title_full Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review
title_fullStr Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review
title_full_unstemmed Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review
title_short Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review
title_sort blood fatty acid status and clinical outcomes in dialysis patients: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213187/
https://www.ncbi.nlm.nih.gov/pubmed/30248953
http://dx.doi.org/10.3390/nu10101353
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