Tuberous sclerosis complex is required for tumor maintenance in MYC‐driven Burkitt's lymphoma

The tuberous sclerosis complex (TSC) 1/2 is a negative regulator of the nutrient‐sensing kinase mechanistic target of rapamycin complex (mTORC1), and its function is generally associated with tumor suppression. Nevertheless, biallelic loss of function of TSC1 or TSC2 is rarely found in malignant tum...

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Detalles Bibliográficos
Autores principales: Hartleben, Götz, Müller, Christine, Krämer, Andreas, Schimmel, Heiko, Zidek, Laura M, Dornblut, Carsten, Winkler, René, Eichwald, Sabrina, Kortman, Gertrud, Kosan, Christian, Kluiver, Joost, Petersen, Iver, van den Berg, Anke, Wang, Zhao‐Qi, Calkhoven, Cornelis F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213278/
https://www.ncbi.nlm.nih.gov/pubmed/30237309
http://dx.doi.org/10.15252/embj.201798589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213278/
https://www.ncbi.nlm.nih.gov/pubmed/30237309
http://dx.doi.org/10.15252/embj.201798589

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