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Tuberous sclerosis complex is required for tumor maintenance in MYC‐driven Burkitt's lymphoma
The tuberous sclerosis complex (TSC) 1/2 is a negative regulator of the nutrient‐sensing kinase mechanistic target of rapamycin complex (mTORC1), and its function is generally associated with tumor suppression. Nevertheless, biallelic loss of function of TSC1 or TSC2 is rarely found in malignant tum...
Autores principales: | Hartleben, Götz, Müller, Christine, Krämer, Andreas, Schimmel, Heiko, Zidek, Laura M, Dornblut, Carsten, Winkler, René, Eichwald, Sabrina, Kortman, Gertrud, Kosan, Christian, Kluiver, Joost, Petersen, Iver, van den Berg, Anke, Wang, Zhao‐Qi, Calkhoven, Cornelis F |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213278/ https://www.ncbi.nlm.nih.gov/pubmed/30237309 http://dx.doi.org/10.15252/embj.201798589 |
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