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Viruses.STRING: A Virus-Host Protein-Protein Interaction Database

As viruses continue to pose risks to global health, having a better understanding of virus–host protein–protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein–protein interaction database specifically catering to virus–virus and virus–ho...

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Autores principales: Cook, Helen Victoria, Doncheva, Nadezhda Tsankova, Szklarczyk, Damian, von Mering, Christian, Jensen, Lars Juhl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213343/
https://www.ncbi.nlm.nih.gov/pubmed/30249048
http://dx.doi.org/10.3390/v10100519
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author Cook, Helen Victoria
Doncheva, Nadezhda Tsankova
Szklarczyk, Damian
von Mering, Christian
Jensen, Lars Juhl
author_facet Cook, Helen Victoria
Doncheva, Nadezhda Tsankova
Szklarczyk, Damian
von Mering, Christian
Jensen, Lars Juhl
author_sort Cook, Helen Victoria
collection PubMed
description As viruses continue to pose risks to global health, having a better understanding of virus–host protein–protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein–protein interaction database specifically catering to virus–virus and virus–host interactions. This database combines evidence from experimental and text-mining channels to provide combined probabilities for interactions between viral and host proteins. The database contains 177,425 interactions between 239 viruses and 319 hosts. The database is publicly available at viruses.string-db.org, and the interaction data can also be accessed through the latest version of the Cytoscape STRING app.
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spelling pubmed-62133432018-11-09 Viruses.STRING: A Virus-Host Protein-Protein Interaction Database Cook, Helen Victoria Doncheva, Nadezhda Tsankova Szklarczyk, Damian von Mering, Christian Jensen, Lars Juhl Viruses Article As viruses continue to pose risks to global health, having a better understanding of virus–host protein–protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein–protein interaction database specifically catering to virus–virus and virus–host interactions. This database combines evidence from experimental and text-mining channels to provide combined probabilities for interactions between viral and host proteins. The database contains 177,425 interactions between 239 viruses and 319 hosts. The database is publicly available at viruses.string-db.org, and the interaction data can also be accessed through the latest version of the Cytoscape STRING app. MDPI 2018-09-23 /pmc/articles/PMC6213343/ /pubmed/30249048 http://dx.doi.org/10.3390/v10100519 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cook, Helen Victoria
Doncheva, Nadezhda Tsankova
Szklarczyk, Damian
von Mering, Christian
Jensen, Lars Juhl
Viruses.STRING: A Virus-Host Protein-Protein Interaction Database
title Viruses.STRING: A Virus-Host Protein-Protein Interaction Database
title_full Viruses.STRING: A Virus-Host Protein-Protein Interaction Database
title_fullStr Viruses.STRING: A Virus-Host Protein-Protein Interaction Database
title_full_unstemmed Viruses.STRING: A Virus-Host Protein-Protein Interaction Database
title_short Viruses.STRING: A Virus-Host Protein-Protein Interaction Database
title_sort viruses.string: a virus-host protein-protein interaction database
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213343/
https://www.ncbi.nlm.nih.gov/pubmed/30249048
http://dx.doi.org/10.3390/v10100519
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