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Viruses.STRING: A Virus-Host Protein-Protein Interaction Database
As viruses continue to pose risks to global health, having a better understanding of virus–host protein–protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein–protein interaction database specifically catering to virus–virus and virus–ho...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213343/ https://www.ncbi.nlm.nih.gov/pubmed/30249048 http://dx.doi.org/10.3390/v10100519 |
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author | Cook, Helen Victoria Doncheva, Nadezhda Tsankova Szklarczyk, Damian von Mering, Christian Jensen, Lars Juhl |
author_facet | Cook, Helen Victoria Doncheva, Nadezhda Tsankova Szklarczyk, Damian von Mering, Christian Jensen, Lars Juhl |
author_sort | Cook, Helen Victoria |
collection | PubMed |
description | As viruses continue to pose risks to global health, having a better understanding of virus–host protein–protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein–protein interaction database specifically catering to virus–virus and virus–host interactions. This database combines evidence from experimental and text-mining channels to provide combined probabilities for interactions between viral and host proteins. The database contains 177,425 interactions between 239 viruses and 319 hosts. The database is publicly available at viruses.string-db.org, and the interaction data can also be accessed through the latest version of the Cytoscape STRING app. |
format | Online Article Text |
id | pubmed-6213343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62133432018-11-09 Viruses.STRING: A Virus-Host Protein-Protein Interaction Database Cook, Helen Victoria Doncheva, Nadezhda Tsankova Szklarczyk, Damian von Mering, Christian Jensen, Lars Juhl Viruses Article As viruses continue to pose risks to global health, having a better understanding of virus–host protein–protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein–protein interaction database specifically catering to virus–virus and virus–host interactions. This database combines evidence from experimental and text-mining channels to provide combined probabilities for interactions between viral and host proteins. The database contains 177,425 interactions between 239 viruses and 319 hosts. The database is publicly available at viruses.string-db.org, and the interaction data can also be accessed through the latest version of the Cytoscape STRING app. MDPI 2018-09-23 /pmc/articles/PMC6213343/ /pubmed/30249048 http://dx.doi.org/10.3390/v10100519 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cook, Helen Victoria Doncheva, Nadezhda Tsankova Szklarczyk, Damian von Mering, Christian Jensen, Lars Juhl Viruses.STRING: A Virus-Host Protein-Protein Interaction Database |
title | Viruses.STRING: A Virus-Host Protein-Protein Interaction Database |
title_full | Viruses.STRING: A Virus-Host Protein-Protein Interaction Database |
title_fullStr | Viruses.STRING: A Virus-Host Protein-Protein Interaction Database |
title_full_unstemmed | Viruses.STRING: A Virus-Host Protein-Protein Interaction Database |
title_short | Viruses.STRING: A Virus-Host Protein-Protein Interaction Database |
title_sort | viruses.string: a virus-host protein-protein interaction database |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213343/ https://www.ncbi.nlm.nih.gov/pubmed/30249048 http://dx.doi.org/10.3390/v10100519 |
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