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Role of Extracellular Matrix in Development and Cancer Progression

The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The...

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Detalles Bibliográficos
Autores principales: Walker, Cameron, Mojares, Elijah, del Río Hernández, Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213383/
https://www.ncbi.nlm.nih.gov/pubmed/30287763
http://dx.doi.org/10.3390/ijms19103028
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author Walker, Cameron
Mojares, Elijah
del Río Hernández, Armando
author_facet Walker, Cameron
Mojares, Elijah
del Río Hernández, Armando
author_sort Walker, Cameron
collection PubMed
description The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The ECM’s composition and organization are spatiotemporally regulated to control cell behaviour and differentiation, but dysregulation of ECM dynamics leads to the development of diseases such as cancer. The chemical cues presented by the ECM have been appreciated as key drivers for both development and cancer progression. However, the mechanical forces present due to the ECM have been largely ignored but recently recognized to play critical roles in disease progression and malignant cell behaviour. Here, we review the ways in which biophysical forces of the microenvironment influence biochemical regulation and cell phenotype during key stages of human development and cancer progression.
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spelling pubmed-62133832018-11-14 Role of Extracellular Matrix in Development and Cancer Progression Walker, Cameron Mojares, Elijah del Río Hernández, Armando Int J Mol Sci Review The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The ECM’s composition and organization are spatiotemporally regulated to control cell behaviour and differentiation, but dysregulation of ECM dynamics leads to the development of diseases such as cancer. The chemical cues presented by the ECM have been appreciated as key drivers for both development and cancer progression. However, the mechanical forces present due to the ECM have been largely ignored but recently recognized to play critical roles in disease progression and malignant cell behaviour. Here, we review the ways in which biophysical forces of the microenvironment influence biochemical regulation and cell phenotype during key stages of human development and cancer progression. MDPI 2018-10-04 /pmc/articles/PMC6213383/ /pubmed/30287763 http://dx.doi.org/10.3390/ijms19103028 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Walker, Cameron
Mojares, Elijah
del Río Hernández, Armando
Role of Extracellular Matrix in Development and Cancer Progression
title Role of Extracellular Matrix in Development and Cancer Progression
title_full Role of Extracellular Matrix in Development and Cancer Progression
title_fullStr Role of Extracellular Matrix in Development and Cancer Progression
title_full_unstemmed Role of Extracellular Matrix in Development and Cancer Progression
title_short Role of Extracellular Matrix in Development and Cancer Progression
title_sort role of extracellular matrix in development and cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213383/
https://www.ncbi.nlm.nih.gov/pubmed/30287763
http://dx.doi.org/10.3390/ijms19103028
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