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Role of Extracellular Matrix in Development and Cancer Progression
The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213383/ https://www.ncbi.nlm.nih.gov/pubmed/30287763 http://dx.doi.org/10.3390/ijms19103028 |
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author | Walker, Cameron Mojares, Elijah del Río Hernández, Armando |
author_facet | Walker, Cameron Mojares, Elijah del Río Hernández, Armando |
author_sort | Walker, Cameron |
collection | PubMed |
description | The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The ECM’s composition and organization are spatiotemporally regulated to control cell behaviour and differentiation, but dysregulation of ECM dynamics leads to the development of diseases such as cancer. The chemical cues presented by the ECM have been appreciated as key drivers for both development and cancer progression. However, the mechanical forces present due to the ECM have been largely ignored but recently recognized to play critical roles in disease progression and malignant cell behaviour. Here, we review the ways in which biophysical forces of the microenvironment influence biochemical regulation and cell phenotype during key stages of human development and cancer progression. |
format | Online Article Text |
id | pubmed-6213383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62133832018-11-14 Role of Extracellular Matrix in Development and Cancer Progression Walker, Cameron Mojares, Elijah del Río Hernández, Armando Int J Mol Sci Review The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The ECM’s composition and organization are spatiotemporally regulated to control cell behaviour and differentiation, but dysregulation of ECM dynamics leads to the development of diseases such as cancer. The chemical cues presented by the ECM have been appreciated as key drivers for both development and cancer progression. However, the mechanical forces present due to the ECM have been largely ignored but recently recognized to play critical roles in disease progression and malignant cell behaviour. Here, we review the ways in which biophysical forces of the microenvironment influence biochemical regulation and cell phenotype during key stages of human development and cancer progression. MDPI 2018-10-04 /pmc/articles/PMC6213383/ /pubmed/30287763 http://dx.doi.org/10.3390/ijms19103028 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Walker, Cameron Mojares, Elijah del Río Hernández, Armando Role of Extracellular Matrix in Development and Cancer Progression |
title | Role of Extracellular Matrix in Development and Cancer Progression |
title_full | Role of Extracellular Matrix in Development and Cancer Progression |
title_fullStr | Role of Extracellular Matrix in Development and Cancer Progression |
title_full_unstemmed | Role of Extracellular Matrix in Development and Cancer Progression |
title_short | Role of Extracellular Matrix in Development and Cancer Progression |
title_sort | role of extracellular matrix in development and cancer progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213383/ https://www.ncbi.nlm.nih.gov/pubmed/30287763 http://dx.doi.org/10.3390/ijms19103028 |
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