Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma

Despite the significant recent achievements in the diagnosis and treatment of colorectal cancer (CRC), the prognosis of these patients has currently plateaued. During the past few years, the opportunity to consider multiple treatment modalities (including surgery and other locoregional treatments, s...

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Autores principales: Lopez, Gianluca, Boggio, Francesca, Ferrero, Stefano, Fusco, Nicola, Del Gobbo, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213422/
https://www.ncbi.nlm.nih.gov/pubmed/30282914
http://dx.doi.org/10.3390/ijms19103014
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author Lopez, Gianluca
Boggio, Francesca
Ferrero, Stefano
Fusco, Nicola
Del Gobbo, Alessandro
author_facet Lopez, Gianluca
Boggio, Francesca
Ferrero, Stefano
Fusco, Nicola
Del Gobbo, Alessandro
author_sort Lopez, Gianluca
collection PubMed
description Despite the significant recent achievements in the diagnosis and treatment of colorectal cancer (CRC), the prognosis of these patients has currently plateaued. During the past few years, the opportunity to consider multiple treatment modalities (including surgery and other locoregional treatments, systemic therapy, and targeted therapy) led to the research of novel prognostic and predictive biomarkers in CRC liver metastases (CRCLM) patients. In this review, we seek to describe the current state of knowledge of CRCLM biomarkers and to outline impending clinical perspectives, in particular focusing on the cutting-edge tools available for their characterization.
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spelling pubmed-62134222018-11-14 Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma Lopez, Gianluca Boggio, Francesca Ferrero, Stefano Fusco, Nicola Del Gobbo, Alessandro Int J Mol Sci Review Despite the significant recent achievements in the diagnosis and treatment of colorectal cancer (CRC), the prognosis of these patients has currently plateaued. During the past few years, the opportunity to consider multiple treatment modalities (including surgery and other locoregional treatments, systemic therapy, and targeted therapy) led to the research of novel prognostic and predictive biomarkers in CRC liver metastases (CRCLM) patients. In this review, we seek to describe the current state of knowledge of CRCLM biomarkers and to outline impending clinical perspectives, in particular focusing on the cutting-edge tools available for their characterization. MDPI 2018-10-03 /pmc/articles/PMC6213422/ /pubmed/30282914 http://dx.doi.org/10.3390/ijms19103014 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lopez, Gianluca
Boggio, Francesca
Ferrero, Stefano
Fusco, Nicola
Del Gobbo, Alessandro
Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma
title Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma
title_full Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma
title_fullStr Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma
title_full_unstemmed Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma
title_short Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma
title_sort molecular and immunohistochemical markers with prognostic and predictive significance in liver metastases from colorectal carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213422/
https://www.ncbi.nlm.nih.gov/pubmed/30282914
http://dx.doi.org/10.3390/ijms19103014
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