Cargando…
Effect of Moringa oleifera Leaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps
The hypoglycemic effect in humans of Moringa oleifera (MO) leaf powder has, to date, been poorly investigated. We assessed the chemical composition of MO leaf powder produced at Saharawi refugee camps, its in vitro ability to inhibit α-amylase activity, and its sensory acceptability in food. We then...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213450/ https://www.ncbi.nlm.nih.gov/pubmed/30322091 http://dx.doi.org/10.3390/nu10101494 |
_version_ | 1783367771536490496 |
---|---|
author | Leone, Alessandro Bertoli, Simona Di Lello, Sara Bassoli, Angela Ravasenghi, Stefano Borgonovo, Gigliola Forlani, Fabio Battezzati, Alberto |
author_facet | Leone, Alessandro Bertoli, Simona Di Lello, Sara Bassoli, Angela Ravasenghi, Stefano Borgonovo, Gigliola Forlani, Fabio Battezzati, Alberto |
author_sort | Leone, Alessandro |
collection | PubMed |
description | The hypoglycemic effect in humans of Moringa oleifera (MO) leaf powder has, to date, been poorly investigated. We assessed the chemical composition of MO leaf powder produced at Saharawi refugee camps, its in vitro ability to inhibit α-amylase activity, and its sensory acceptability in food. We then evaluated its effect on postprandial glucose response by randomly administering, on 2 different days, a traditional meal supplemented with 20 g of MO leaf powder (MOR20), or not (control meal, CNT), to 17 Saharawi diabetics and 10 healthy subjects. Capillary glycaemia was measured immediately before the meal and then at 30 min intervals for 3 h. In the diabetic subjects the postprandial glucose response peaked earlier with MOR20 compared to CNT and with lower increments at 90, 120, and 150 min. The mean glycemic meal response with MOR20 was lower than with CNT. The healthy subjects showed no differences. Thus, MO leaf powder could be a hypoglycemic herbal drug. However, given the poor taste acceptability of the 20 g MO meal, lower doses should be evaluated. Moreover, the hypoglycemic effects of MO leaf powder should also be demonstrated by trials evaluating its long-term effects on glycaemia. |
format | Online Article Text |
id | pubmed-6213450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62134502018-11-06 Effect of Moringa oleifera Leaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps Leone, Alessandro Bertoli, Simona Di Lello, Sara Bassoli, Angela Ravasenghi, Stefano Borgonovo, Gigliola Forlani, Fabio Battezzati, Alberto Nutrients Article The hypoglycemic effect in humans of Moringa oleifera (MO) leaf powder has, to date, been poorly investigated. We assessed the chemical composition of MO leaf powder produced at Saharawi refugee camps, its in vitro ability to inhibit α-amylase activity, and its sensory acceptability in food. We then evaluated its effect on postprandial glucose response by randomly administering, on 2 different days, a traditional meal supplemented with 20 g of MO leaf powder (MOR20), or not (control meal, CNT), to 17 Saharawi diabetics and 10 healthy subjects. Capillary glycaemia was measured immediately before the meal and then at 30 min intervals for 3 h. In the diabetic subjects the postprandial glucose response peaked earlier with MOR20 compared to CNT and with lower increments at 90, 120, and 150 min. The mean glycemic meal response with MOR20 was lower than with CNT. The healthy subjects showed no differences. Thus, MO leaf powder could be a hypoglycemic herbal drug. However, given the poor taste acceptability of the 20 g MO meal, lower doses should be evaluated. Moreover, the hypoglycemic effects of MO leaf powder should also be demonstrated by trials evaluating its long-term effects on glycaemia. MDPI 2018-10-12 /pmc/articles/PMC6213450/ /pubmed/30322091 http://dx.doi.org/10.3390/nu10101494 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Leone, Alessandro Bertoli, Simona Di Lello, Sara Bassoli, Angela Ravasenghi, Stefano Borgonovo, Gigliola Forlani, Fabio Battezzati, Alberto Effect of Moringa oleifera Leaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps |
title | Effect of Moringa oleifera Leaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps |
title_full | Effect of Moringa oleifera Leaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps |
title_fullStr | Effect of Moringa oleifera Leaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps |
title_full_unstemmed | Effect of Moringa oleifera Leaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps |
title_short | Effect of Moringa oleifera Leaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps |
title_sort | effect of moringa oleifera leaf powder on postprandial blood glucose response: in vivo study on saharawi people living in refugee camps |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213450/ https://www.ncbi.nlm.nih.gov/pubmed/30322091 http://dx.doi.org/10.3390/nu10101494 |
work_keys_str_mv | AT leonealessandro effectofmoringaoleiferaleafpowderonpostprandialbloodglucoseresponseinvivostudyonsaharawipeoplelivinginrefugeecamps AT bertolisimona effectofmoringaoleiferaleafpowderonpostprandialbloodglucoseresponseinvivostudyonsaharawipeoplelivinginrefugeecamps AT dilellosara effectofmoringaoleiferaleafpowderonpostprandialbloodglucoseresponseinvivostudyonsaharawipeoplelivinginrefugeecamps AT bassoliangela effectofmoringaoleiferaleafpowderonpostprandialbloodglucoseresponseinvivostudyonsaharawipeoplelivinginrefugeecamps AT ravasenghistefano effectofmoringaoleiferaleafpowderonpostprandialbloodglucoseresponseinvivostudyonsaharawipeoplelivinginrefugeecamps AT borgonovogigliola effectofmoringaoleiferaleafpowderonpostprandialbloodglucoseresponseinvivostudyonsaharawipeoplelivinginrefugeecamps AT forlanifabio effectofmoringaoleiferaleafpowderonpostprandialbloodglucoseresponseinvivostudyonsaharawipeoplelivinginrefugeecamps AT battezzatialberto effectofmoringaoleiferaleafpowderonpostprandialbloodglucoseresponseinvivostudyonsaharawipeoplelivinginrefugeecamps |