Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches

Dinitroanilines are chemical compounds with high selectivity for plant cell α-tubulin in which they promote microtubule depolymerization. They target α-tubulin regions that have diverged over evolution and show no effect on non-photosynthetic eukaryotes. Hence, they have been used as herbicides over...

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Detalles Bibliográficos
Autores principales: Soleilhac, Emmanuelle, Brillet-Guéguen, Loraine, Roussel, Véronique, Prudent, Renaud, Touquet, Bastien, Dass, Sheena, Aci-Sèche, Samia, Kasam, Vinod, Barette, Caroline, Imberty, Anne, Breton, Vincent, Vantard, Marylin, Horvath, Dragos, Botté, Cyrille, Tardieux, Isabelle, Roy, Sylvaine, Maréchal, Eric, Lafanechère, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213459/
https://www.ncbi.nlm.nih.gov/pubmed/30304836
http://dx.doi.org/10.3390/ijms19103085

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