Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals

Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is to regulate cell death. DAPK family proteins consist of DAPK1, DAPK2, DAPK3, DAPK-related apoptosis-inducing protein kinases (DRAK)-1 and DRAK-2. In this review, we discuss the role...

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Autores principales: Elbadawy, Mohamed, Usui, Tatsuya, Yamawaki, Hideyuki, Sasaki, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213522/
https://www.ncbi.nlm.nih.gov/pubmed/30287790
http://dx.doi.org/10.3390/ijms19103031
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author Elbadawy, Mohamed
Usui, Tatsuya
Yamawaki, Hideyuki
Sasaki, Kazuaki
author_facet Elbadawy, Mohamed
Usui, Tatsuya
Yamawaki, Hideyuki
Sasaki, Kazuaki
author_sort Elbadawy, Mohamed
collection PubMed
description Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is to regulate cell death. DAPK family proteins consist of DAPK1, DAPK2, DAPK3, DAPK-related apoptosis-inducing protein kinases (DRAK)-1 and DRAK-2. In this review, we discuss the roles and regulatory mechanisms of DAPK family members and their relevance to diseases. Furthermore, a special focus is given to several reports describing cross-talks between DAPKs and mitogen-activated protein kinases (MAPK) family members in various pathologies. We also discuss small molecule inhibitors of DAPKs and their potential as therapeutic targets against human diseases.
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spelling pubmed-62135222018-11-14 Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals Elbadawy, Mohamed Usui, Tatsuya Yamawaki, Hideyuki Sasaki, Kazuaki Int J Mol Sci Article Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is to regulate cell death. DAPK family proteins consist of DAPK1, DAPK2, DAPK3, DAPK-related apoptosis-inducing protein kinases (DRAK)-1 and DRAK-2. In this review, we discuss the roles and regulatory mechanisms of DAPK family members and their relevance to diseases. Furthermore, a special focus is given to several reports describing cross-talks between DAPKs and mitogen-activated protein kinases (MAPK) family members in various pathologies. We also discuss small molecule inhibitors of DAPKs and their potential as therapeutic targets against human diseases. MDPI 2018-10-04 /pmc/articles/PMC6213522/ /pubmed/30287790 http://dx.doi.org/10.3390/ijms19103031 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Elbadawy, Mohamed
Usui, Tatsuya
Yamawaki, Hideyuki
Sasaki, Kazuaki
Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals
title Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals
title_full Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals
title_fullStr Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals
title_full_unstemmed Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals
title_short Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals
title_sort novel functions of death-associated protein kinases through mitogen-activated protein kinase-related signals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213522/
https://www.ncbi.nlm.nih.gov/pubmed/30287790
http://dx.doi.org/10.3390/ijms19103031
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