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ZKSCAN3 Upregulation and Its Poor Clinical Outcome in Uterine Cervical Cancer
Zinc finger with KRAB and SCAN domain 3 (ZKSCAN3) upregulates genes encoding proteins involved in cell differentiation, proliferation and apoptosis. ZKSCAN3 has been reported to be overexpressed in several human cancers such as colorectal cancer and prostate cancer and is proposed as a candidate onc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213532/ https://www.ncbi.nlm.nih.gov/pubmed/30241382 http://dx.doi.org/10.3390/ijms19102859 |
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author | Lee, Sun Cho, Young-Eun Kim, Joo-Young Park, Jae-Hoon |
author_facet | Lee, Sun Cho, Young-Eun Kim, Joo-Young Park, Jae-Hoon |
author_sort | Lee, Sun |
collection | PubMed |
description | Zinc finger with KRAB and SCAN domain 3 (ZKSCAN3) upregulates genes encoding proteins involved in cell differentiation, proliferation and apoptosis. ZKSCAN3 has been reported to be overexpressed in several human cancers such as colorectal cancer and prostate cancer and is proposed as a candidate oncoprotein. However, the molecular mechanism by which ZKSCAN3 participates in carcinogenesis is largely unknown. Here, we evaluated ZKSCAN3 expression in uterine cervical cancers (CC) by immunohistochemistry using formalin-fixed, paraffin-embedded tissues from 126 biopsy samples from 126 patients. The clinicopathological findings were analyzed and compared with ZKSCAN3 expression levels. ZKSCAN3 was strongly overexpressed in CCs compared to adjacent non-neoplastic cervical mucosa tissues. Moreover, a gene copy number assay showed amplified ZKSCAN3 in CC samples. ZKSCAN3 overexpression was also significantly associated with poor overall survival of the patients. Overall, our findings indicate that ZKSCAN3 overexpression is a frequent event in uterine CC and is correlated with a poor clinical outcome. ZKSCAN3 could be developed as a molecular marker for prognostic prediction and early detection. |
format | Online Article Text |
id | pubmed-6213532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62135322018-11-14 ZKSCAN3 Upregulation and Its Poor Clinical Outcome in Uterine Cervical Cancer Lee, Sun Cho, Young-Eun Kim, Joo-Young Park, Jae-Hoon Int J Mol Sci Article Zinc finger with KRAB and SCAN domain 3 (ZKSCAN3) upregulates genes encoding proteins involved in cell differentiation, proliferation and apoptosis. ZKSCAN3 has been reported to be overexpressed in several human cancers such as colorectal cancer and prostate cancer and is proposed as a candidate oncoprotein. However, the molecular mechanism by which ZKSCAN3 participates in carcinogenesis is largely unknown. Here, we evaluated ZKSCAN3 expression in uterine cervical cancers (CC) by immunohistochemistry using formalin-fixed, paraffin-embedded tissues from 126 biopsy samples from 126 patients. The clinicopathological findings were analyzed and compared with ZKSCAN3 expression levels. ZKSCAN3 was strongly overexpressed in CCs compared to adjacent non-neoplastic cervical mucosa tissues. Moreover, a gene copy number assay showed amplified ZKSCAN3 in CC samples. ZKSCAN3 overexpression was also significantly associated with poor overall survival of the patients. Overall, our findings indicate that ZKSCAN3 overexpression is a frequent event in uterine CC and is correlated with a poor clinical outcome. ZKSCAN3 could be developed as a molecular marker for prognostic prediction and early detection. MDPI 2018-09-20 /pmc/articles/PMC6213532/ /pubmed/30241382 http://dx.doi.org/10.3390/ijms19102859 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Sun Cho, Young-Eun Kim, Joo-Young Park, Jae-Hoon ZKSCAN3 Upregulation and Its Poor Clinical Outcome in Uterine Cervical Cancer |
title | ZKSCAN3 Upregulation and Its Poor Clinical Outcome in Uterine Cervical Cancer |
title_full | ZKSCAN3 Upregulation and Its Poor Clinical Outcome in Uterine Cervical Cancer |
title_fullStr | ZKSCAN3 Upregulation and Its Poor Clinical Outcome in Uterine Cervical Cancer |
title_full_unstemmed | ZKSCAN3 Upregulation and Its Poor Clinical Outcome in Uterine Cervical Cancer |
title_short | ZKSCAN3 Upregulation and Its Poor Clinical Outcome in Uterine Cervical Cancer |
title_sort | zkscan3 upregulation and its poor clinical outcome in uterine cervical cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213532/ https://www.ncbi.nlm.nih.gov/pubmed/30241382 http://dx.doi.org/10.3390/ijms19102859 |
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