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Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation

Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regula...

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Autores principales: Lyons, Claire L., Roche, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213547/
https://www.ncbi.nlm.nih.gov/pubmed/30304866
http://dx.doi.org/10.3390/ijms19103092
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author Lyons, Claire L.
Roche, Helen M.
author_facet Lyons, Claire L.
Roche, Helen M.
author_sort Lyons, Claire L.
collection PubMed
description Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequent negative downstream effects on glucose, lipid and insulin metabolism. Nutrient stress in the form of obesity can impact AMPK and whole-body metabolism, leading to complications such as type 2 diabetes and cancer risk. There is a lack of data regarding the nature and extent that nutrient status has on AMPK and metabolic-inflammation. However, emerging work elucidates to a direct role of individual nutrients on AMPK and metabolic-inflammation, as a possible means of modulating AMPK activity. The posit being to use such nutritional agents to re-configure metabolic-inflammation towards more oxidative phosphorylation and promote the resolution of inflammation. The complex paradigm will be discussed within the context of if/how dietary components, nutrients including fatty acids and non-nutrient food components, such as resveratrol, berberine, curcumin and the flavonoid genistein, modulate AMPK dependent processes relating to inflammation and metabolism.
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spelling pubmed-62135472018-11-14 Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation Lyons, Claire L. Roche, Helen M. Int J Mol Sci Review Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequent negative downstream effects on glucose, lipid and insulin metabolism. Nutrient stress in the form of obesity can impact AMPK and whole-body metabolism, leading to complications such as type 2 diabetes and cancer risk. There is a lack of data regarding the nature and extent that nutrient status has on AMPK and metabolic-inflammation. However, emerging work elucidates to a direct role of individual nutrients on AMPK and metabolic-inflammation, as a possible means of modulating AMPK activity. The posit being to use such nutritional agents to re-configure metabolic-inflammation towards more oxidative phosphorylation and promote the resolution of inflammation. The complex paradigm will be discussed within the context of if/how dietary components, nutrients including fatty acids and non-nutrient food components, such as resveratrol, berberine, curcumin and the flavonoid genistein, modulate AMPK dependent processes relating to inflammation and metabolism. MDPI 2018-10-09 /pmc/articles/PMC6213547/ /pubmed/30304866 http://dx.doi.org/10.3390/ijms19103092 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lyons, Claire L.
Roche, Helen M.
Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation
title Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation
title_full Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation
title_fullStr Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation
title_full_unstemmed Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation
title_short Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation
title_sort nutritional modulation of ampk-impact upon metabolic-inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213547/
https://www.ncbi.nlm.nih.gov/pubmed/30304866
http://dx.doi.org/10.3390/ijms19103092
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