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Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives

The increasing emergence of new forms of multidrug resistance among human pathogenic bacteria, coupled with the consequent increase of infectious diseases, urgently requires the discovery and development of novel antimicrobial drugs with new modes of action. Most of the antibiotics currently availab...

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Detalles Bibliográficos
Autores principales: Tortorella, Emiliana, Tedesco, Pietro, Palma Esposito, Fortunato, January, Grant Garren, Fani, Renato, Jaspars, Marcel, de Pascale, Donatella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213577/
https://www.ncbi.nlm.nih.gov/pubmed/30274274
http://dx.doi.org/10.3390/md16100355
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author Tortorella, Emiliana
Tedesco, Pietro
Palma Esposito, Fortunato
January, Grant Garren
Fani, Renato
Jaspars, Marcel
de Pascale, Donatella
author_facet Tortorella, Emiliana
Tedesco, Pietro
Palma Esposito, Fortunato
January, Grant Garren
Fani, Renato
Jaspars, Marcel
de Pascale, Donatella
author_sort Tortorella, Emiliana
collection PubMed
description The increasing emergence of new forms of multidrug resistance among human pathogenic bacteria, coupled with the consequent increase of infectious diseases, urgently requires the discovery and development of novel antimicrobial drugs with new modes of action. Most of the antibiotics currently available on the market were obtained from terrestrial organisms or derived semisynthetically from fermentation products. The isolation of microorganisms from previously unexplored habitats may lead to the discovery of lead structures with antibiotic activity. The deep-sea environment is a unique habitat, and deep-sea microorganisms, because of their adaptation to this extreme environment, have the potential to produce novel secondary metabolites with potent biological activities. This review covers novel antibiotics isolated from deep-sea microorganisms. The chemical classes of the compounds, their bioactivities, and the sources of organisms are outlined. Furthermore, the authors report recent advances in techniques and strategies for the exploitation of deep-sea microorganisms.
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spelling pubmed-62135772018-11-09 Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives Tortorella, Emiliana Tedesco, Pietro Palma Esposito, Fortunato January, Grant Garren Fani, Renato Jaspars, Marcel de Pascale, Donatella Mar Drugs Review The increasing emergence of new forms of multidrug resistance among human pathogenic bacteria, coupled with the consequent increase of infectious diseases, urgently requires the discovery and development of novel antimicrobial drugs with new modes of action. Most of the antibiotics currently available on the market were obtained from terrestrial organisms or derived semisynthetically from fermentation products. The isolation of microorganisms from previously unexplored habitats may lead to the discovery of lead structures with antibiotic activity. The deep-sea environment is a unique habitat, and deep-sea microorganisms, because of their adaptation to this extreme environment, have the potential to produce novel secondary metabolites with potent biological activities. This review covers novel antibiotics isolated from deep-sea microorganisms. The chemical classes of the compounds, their bioactivities, and the sources of organisms are outlined. Furthermore, the authors report recent advances in techniques and strategies for the exploitation of deep-sea microorganisms. MDPI 2018-09-29 /pmc/articles/PMC6213577/ /pubmed/30274274 http://dx.doi.org/10.3390/md16100355 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tortorella, Emiliana
Tedesco, Pietro
Palma Esposito, Fortunato
January, Grant Garren
Fani, Renato
Jaspars, Marcel
de Pascale, Donatella
Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives
title Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives
title_full Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives
title_fullStr Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives
title_full_unstemmed Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives
title_short Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives
title_sort antibiotics from deep-sea microorganisms: current discoveries and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213577/
https://www.ncbi.nlm.nih.gov/pubmed/30274274
http://dx.doi.org/10.3390/md16100355
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