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Multifunctional Cargo-Free Nanomedicine for Cancer Therapy

Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass ex...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Yang, Pengfei, Zhao, Xinrui, Gao, Di, Sun, Na, Tian, Zhongmin, Ma, Tianyou, Yang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213727/
https://www.ncbi.nlm.nih.gov/pubmed/30274177
http://dx.doi.org/10.3390/ijms19102963
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author Wang, Ying
Yang, Pengfei
Zhao, Xinrui
Gao, Di
Sun, Na
Tian, Zhongmin
Ma, Tianyou
Yang, Zhe
author_facet Wang, Ying
Yang, Pengfei
Zhao, Xinrui
Gao, Di
Sun, Na
Tian, Zhongmin
Ma, Tianyou
Yang, Zhe
author_sort Wang, Ying
collection PubMed
description Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass extensive clinical trials to be drug excipients before any clinical applications. Cargo-free nanomedicines, which are fabricated by drugs themselves without new excipients and possess nanoscale characteristics to realize favorable pharmacokinetics and intracellular delivery, have been rapidly developed and drawn much attention to cancer treatment. Herein, we discuss recent advances of cargo-free nanomedicines for cancer treatment. After a brief introduction to the major types of carrier-free nanomedicine, some representative applications of these cargo-free nanomedicines are discussed, including combination therapy, immunotherapy, as well as self-monitoring of drug release. More importantly, this review draws a brief conclusion and discusses the future challenges of cargo-free nanomedicines from our perspective.
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spelling pubmed-62137272018-11-14 Multifunctional Cargo-Free Nanomedicine for Cancer Therapy Wang, Ying Yang, Pengfei Zhao, Xinrui Gao, Di Sun, Na Tian, Zhongmin Ma, Tianyou Yang, Zhe Int J Mol Sci Review Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass extensive clinical trials to be drug excipients before any clinical applications. Cargo-free nanomedicines, which are fabricated by drugs themselves without new excipients and possess nanoscale characteristics to realize favorable pharmacokinetics and intracellular delivery, have been rapidly developed and drawn much attention to cancer treatment. Herein, we discuss recent advances of cargo-free nanomedicines for cancer treatment. After a brief introduction to the major types of carrier-free nanomedicine, some representative applications of these cargo-free nanomedicines are discussed, including combination therapy, immunotherapy, as well as self-monitoring of drug release. More importantly, this review draws a brief conclusion and discusses the future challenges of cargo-free nanomedicines from our perspective. MDPI 2018-09-28 /pmc/articles/PMC6213727/ /pubmed/30274177 http://dx.doi.org/10.3390/ijms19102963 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Ying
Yang, Pengfei
Zhao, Xinrui
Gao, Di
Sun, Na
Tian, Zhongmin
Ma, Tianyou
Yang, Zhe
Multifunctional Cargo-Free Nanomedicine for Cancer Therapy
title Multifunctional Cargo-Free Nanomedicine for Cancer Therapy
title_full Multifunctional Cargo-Free Nanomedicine for Cancer Therapy
title_fullStr Multifunctional Cargo-Free Nanomedicine for Cancer Therapy
title_full_unstemmed Multifunctional Cargo-Free Nanomedicine for Cancer Therapy
title_short Multifunctional Cargo-Free Nanomedicine for Cancer Therapy
title_sort multifunctional cargo-free nanomedicine for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213727/
https://www.ncbi.nlm.nih.gov/pubmed/30274177
http://dx.doi.org/10.3390/ijms19102963
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