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Multifunctional Cargo-Free Nanomedicine for Cancer Therapy
Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass ex...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213727/ https://www.ncbi.nlm.nih.gov/pubmed/30274177 http://dx.doi.org/10.3390/ijms19102963 |
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author | Wang, Ying Yang, Pengfei Zhao, Xinrui Gao, Di Sun, Na Tian, Zhongmin Ma, Tianyou Yang, Zhe |
author_facet | Wang, Ying Yang, Pengfei Zhao, Xinrui Gao, Di Sun, Na Tian, Zhongmin Ma, Tianyou Yang, Zhe |
author_sort | Wang, Ying |
collection | PubMed |
description | Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass extensive clinical trials to be drug excipients before any clinical applications. Cargo-free nanomedicines, which are fabricated by drugs themselves without new excipients and possess nanoscale characteristics to realize favorable pharmacokinetics and intracellular delivery, have been rapidly developed and drawn much attention to cancer treatment. Herein, we discuss recent advances of cargo-free nanomedicines for cancer treatment. After a brief introduction to the major types of carrier-free nanomedicine, some representative applications of these cargo-free nanomedicines are discussed, including combination therapy, immunotherapy, as well as self-monitoring of drug release. More importantly, this review draws a brief conclusion and discusses the future challenges of cargo-free nanomedicines from our perspective. |
format | Online Article Text |
id | pubmed-6213727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62137272018-11-14 Multifunctional Cargo-Free Nanomedicine for Cancer Therapy Wang, Ying Yang, Pengfei Zhao, Xinrui Gao, Di Sun, Na Tian, Zhongmin Ma, Tianyou Yang, Zhe Int J Mol Sci Review Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass extensive clinical trials to be drug excipients before any clinical applications. Cargo-free nanomedicines, which are fabricated by drugs themselves without new excipients and possess nanoscale characteristics to realize favorable pharmacokinetics and intracellular delivery, have been rapidly developed and drawn much attention to cancer treatment. Herein, we discuss recent advances of cargo-free nanomedicines for cancer treatment. After a brief introduction to the major types of carrier-free nanomedicine, some representative applications of these cargo-free nanomedicines are discussed, including combination therapy, immunotherapy, as well as self-monitoring of drug release. More importantly, this review draws a brief conclusion and discusses the future challenges of cargo-free nanomedicines from our perspective. MDPI 2018-09-28 /pmc/articles/PMC6213727/ /pubmed/30274177 http://dx.doi.org/10.3390/ijms19102963 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Ying Yang, Pengfei Zhao, Xinrui Gao, Di Sun, Na Tian, Zhongmin Ma, Tianyou Yang, Zhe Multifunctional Cargo-Free Nanomedicine for Cancer Therapy |
title | Multifunctional Cargo-Free Nanomedicine for Cancer Therapy |
title_full | Multifunctional Cargo-Free Nanomedicine for Cancer Therapy |
title_fullStr | Multifunctional Cargo-Free Nanomedicine for Cancer Therapy |
title_full_unstemmed | Multifunctional Cargo-Free Nanomedicine for Cancer Therapy |
title_short | Multifunctional Cargo-Free Nanomedicine for Cancer Therapy |
title_sort | multifunctional cargo-free nanomedicine for cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213727/ https://www.ncbi.nlm.nih.gov/pubmed/30274177 http://dx.doi.org/10.3390/ijms19102963 |
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