Cargando…
Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice
We tested the effect of chronic low-dose abscisic acid (ABA), a phytohormone-regulating human glucose tolerance, on the metabolic parameters that are dysregulated in prediabetes and metabolic syndrome (MS).Ten healthy subjects received 1 µg ABA/Kg body weight (BW)/day as an ABA-rich food supplement:...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213903/ https://www.ncbi.nlm.nih.gov/pubmed/30322104 http://dx.doi.org/10.3390/nu10101495 |
_version_ | 1783367883409063936 |
---|---|
author | Magnone, Mirko Leoncini, Giovanna Vigliarolo, Tiziana Emionite, Laura Sturla, Laura Zocchi, Elena Murialdo, Giovanni |
author_facet | Magnone, Mirko Leoncini, Giovanna Vigliarolo, Tiziana Emionite, Laura Sturla, Laura Zocchi, Elena Murialdo, Giovanni |
author_sort | Magnone, Mirko |
collection | PubMed |
description | We tested the effect of chronic low-dose abscisic acid (ABA), a phytohormone-regulating human glucose tolerance, on the metabolic parameters that are dysregulated in prediabetes and metabolic syndrome (MS).Ten healthy subjects received 1 µg ABA/Kg body weight (BW)/day as an ABA-rich food supplement: (i) the glycemia profile after a carbohydrate-rich meal, with or without supplement, was compared; (ii) fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), and body mass index (BMI) after 75 days of daily supplementation of a habitual Mediterranean diet were compared with starting values.CD1 mice were fed a high-glucose diet with or without synthetic ABA (1 µg/Kg BW) for 4 months and the same parameters investigated in the human study were compared. The food supplement significantly reduced the area under the curve of glycemia after a carbohydrate-rich meal and FBG, HbA1c, TC, and BMI after chronic treatment. ABA-treated mice showed a significant reduction of HbA1c, TC, and body weight gain compared with untreated controls. The combined results from the human and murine studies allow us to conclude that the observed improvement of the metabolic parameters can be attributed to ABA and to advocate the use of ABA-containing food supplements in prediabetes and/or MS. |
format | Online Article Text |
id | pubmed-6213903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62139032018-11-06 Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice Magnone, Mirko Leoncini, Giovanna Vigliarolo, Tiziana Emionite, Laura Sturla, Laura Zocchi, Elena Murialdo, Giovanni Nutrients Article We tested the effect of chronic low-dose abscisic acid (ABA), a phytohormone-regulating human glucose tolerance, on the metabolic parameters that are dysregulated in prediabetes and metabolic syndrome (MS).Ten healthy subjects received 1 µg ABA/Kg body weight (BW)/day as an ABA-rich food supplement: (i) the glycemia profile after a carbohydrate-rich meal, with or without supplement, was compared; (ii) fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), and body mass index (BMI) after 75 days of daily supplementation of a habitual Mediterranean diet were compared with starting values.CD1 mice were fed a high-glucose diet with or without synthetic ABA (1 µg/Kg BW) for 4 months and the same parameters investigated in the human study were compared. The food supplement significantly reduced the area under the curve of glycemia after a carbohydrate-rich meal and FBG, HbA1c, TC, and BMI after chronic treatment. ABA-treated mice showed a significant reduction of HbA1c, TC, and body weight gain compared with untreated controls. The combined results from the human and murine studies allow us to conclude that the observed improvement of the metabolic parameters can be attributed to ABA and to advocate the use of ABA-containing food supplements in prediabetes and/or MS. MDPI 2018-10-12 /pmc/articles/PMC6213903/ /pubmed/30322104 http://dx.doi.org/10.3390/nu10101495 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Magnone, Mirko Leoncini, Giovanna Vigliarolo, Tiziana Emionite, Laura Sturla, Laura Zocchi, Elena Murialdo, Giovanni Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice |
title | Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice |
title_full | Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice |
title_fullStr | Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice |
title_full_unstemmed | Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice |
title_short | Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice |
title_sort | chronic intake of micrograms of abscisic acid improves glycemia and lipidemia in a human study and in high-glucose fed mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213903/ https://www.ncbi.nlm.nih.gov/pubmed/30322104 http://dx.doi.org/10.3390/nu10101495 |
work_keys_str_mv | AT magnonemirko chronicintakeofmicrogramsofabscisicacidimprovesglycemiaandlipidemiainahumanstudyandinhighglucosefedmice AT leoncinigiovanna chronicintakeofmicrogramsofabscisicacidimprovesglycemiaandlipidemiainahumanstudyandinhighglucosefedmice AT vigliarolotiziana chronicintakeofmicrogramsofabscisicacidimprovesglycemiaandlipidemiainahumanstudyandinhighglucosefedmice AT emionitelaura chronicintakeofmicrogramsofabscisicacidimprovesglycemiaandlipidemiainahumanstudyandinhighglucosefedmice AT sturlalaura chronicintakeofmicrogramsofabscisicacidimprovesglycemiaandlipidemiainahumanstudyandinhighglucosefedmice AT zocchielena chronicintakeofmicrogramsofabscisicacidimprovesglycemiaandlipidemiainahumanstudyandinhighglucosefedmice AT murialdogiovanni chronicintakeofmicrogramsofabscisicacidimprovesglycemiaandlipidemiainahumanstudyandinhighglucosefedmice |