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Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses
The recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated de novo from sequence data an early Asian lineage Z...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213914/ https://www.ncbi.nlm.nih.gov/pubmed/30282919 http://dx.doi.org/10.3390/v10100541 |
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author | Setoh, Yin Xiang Peng, Nias Y. Nakayama, Eri Amarilla, Alberto A. Prow, Natalie A. Suhrbier, Andreas Khromykh, Alexander A. |
author_facet | Setoh, Yin Xiang Peng, Nias Y. Nakayama, Eri Amarilla, Alberto A. Prow, Natalie A. Suhrbier, Andreas Khromykh, Alexander A. |
author_sort | Setoh, Yin Xiang |
collection | PubMed |
description | The recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated de novo from sequence data an early Asian lineage ZIKV isolate (ZIKV-MY; Malaysia, 1966) not associated with microcephaly and compared the in vitro replication kinetics and fetal brain infection in interferon α/β receptor 1 knockout (IFNAR1(−/−)) dams of this isolate and of a Brazilian isolate (ZIKV-Natal; Natal, 2015) unequivocally associated with microcephaly. The replication efficiencies of ZIKV-MY and ZIKV-Natal in A549 and Vero cells were similar, while ZIKV-MY replicated more efficiently in wild-type (WT) and IFNAR(−/−) mouse embryonic fibroblasts. Viremias in IFNAR1(−/−) dams were similar after infection with ZIKV-MY or ZIKV-Natal, and importantly, infection of fetal brains was also not significantly different. Thus, fetal brain infection does not appear to be a unique feature of Brazilian ZIKV isolates. |
format | Online Article Text |
id | pubmed-6213914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62139142018-11-09 Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses Setoh, Yin Xiang Peng, Nias Y. Nakayama, Eri Amarilla, Alberto A. Prow, Natalie A. Suhrbier, Andreas Khromykh, Alexander A. Viruses Communication The recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated de novo from sequence data an early Asian lineage ZIKV isolate (ZIKV-MY; Malaysia, 1966) not associated with microcephaly and compared the in vitro replication kinetics and fetal brain infection in interferon α/β receptor 1 knockout (IFNAR1(−/−)) dams of this isolate and of a Brazilian isolate (ZIKV-Natal; Natal, 2015) unequivocally associated with microcephaly. The replication efficiencies of ZIKV-MY and ZIKV-Natal in A549 and Vero cells were similar, while ZIKV-MY replicated more efficiently in wild-type (WT) and IFNAR(−/−) mouse embryonic fibroblasts. Viremias in IFNAR1(−/−) dams were similar after infection with ZIKV-MY or ZIKV-Natal, and importantly, infection of fetal brains was also not significantly different. Thus, fetal brain infection does not appear to be a unique feature of Brazilian ZIKV isolates. MDPI 2018-10-03 /pmc/articles/PMC6213914/ /pubmed/30282919 http://dx.doi.org/10.3390/v10100541 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Setoh, Yin Xiang Peng, Nias Y. Nakayama, Eri Amarilla, Alberto A. Prow, Natalie A. Suhrbier, Andreas Khromykh, Alexander A. Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
title | Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
title_full | Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
title_fullStr | Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
title_full_unstemmed | Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
title_short | Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
title_sort | fetal brain infection is not a unique characteristic of brazilian zika viruses |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213914/ https://www.ncbi.nlm.nih.gov/pubmed/30282919 http://dx.doi.org/10.3390/v10100541 |
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