Endogenous Omega (n)-3 Fatty Acids in Fat-1 Mice Attenuated Depression-Like Behavior, Imbalance between Microglial M1 and M2 Phenotypes, and Dysfunction of Neurotrophins Induced by Lipopolysaccharide Administration

n-3 polyunsaturated fatty acids (PUFAs) have been reported to improve depression. However, PUFA purities, caloric content, and ratios in different diets may affect the results. By using Fat-1 mice which convert n-6 to n-3 PUFAs in the brain, this study further evaluated anti-depressant mechanisms of...

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Detalles Bibliográficos
Autores principales: Gu, Minqing, Li, Yuyu, Tang, Haiting, Zhang, Cai, Li, Wende, Zhang, Yongping, Li, Yajuan, Zhao, Yuntao, Song, Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213921/
https://www.ncbi.nlm.nih.gov/pubmed/30248907
http://dx.doi.org/10.3390/nu10101351

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