Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum

Four new meroterpenoids 1–4 and four new isocoumarinoids 5–8, along with five known isocoumarinoids (9–13), were isolated from the fungus Myrothecium sp. OUCMDZ-2784 associated with the salt-resistant medicinal plant, Apocynum venetum (Apocynaceae). Their structures were elucidated by means of spect...

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Autores principales: Xu, Yanchao, Wang, Cong, Liu, Haishan, Zhu, Guoliang, Fu, Peng, Wang, Liping, Zhu, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213923/
https://www.ncbi.nlm.nih.gov/pubmed/30275406
http://dx.doi.org/10.3390/md16100363
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author Xu, Yanchao
Wang, Cong
Liu, Haishan
Zhu, Guoliang
Fu, Peng
Wang, Liping
Zhu, Weiming
author_facet Xu, Yanchao
Wang, Cong
Liu, Haishan
Zhu, Guoliang
Fu, Peng
Wang, Liping
Zhu, Weiming
author_sort Xu, Yanchao
collection PubMed
description Four new meroterpenoids 1–4 and four new isocoumarinoids 5–8, along with five known isocoumarinoids (9–13), were isolated from the fungus Myrothecium sp. OUCMDZ-2784 associated with the salt-resistant medicinal plant, Apocynum venetum (Apocynaceae). Their structures were elucidated by means of spectroscopic analysis, X-ray crystallography, ECD spectra and quantum chemical calculations. Compounds 1–5, 7, 9 and 10 showed weak α-glucosidase inhibition with the IC(50) values of 0.50, 0.66, 0.058, 0.20, 0.32, 0.036, 0.026 and 0.37 mM, respectively.
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spelling pubmed-62139232018-11-09 Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum Xu, Yanchao Wang, Cong Liu, Haishan Zhu, Guoliang Fu, Peng Wang, Liping Zhu, Weiming Mar Drugs Article Four new meroterpenoids 1–4 and four new isocoumarinoids 5–8, along with five known isocoumarinoids (9–13), were isolated from the fungus Myrothecium sp. OUCMDZ-2784 associated with the salt-resistant medicinal plant, Apocynum venetum (Apocynaceae). Their structures were elucidated by means of spectroscopic analysis, X-ray crystallography, ECD spectra and quantum chemical calculations. Compounds 1–5, 7, 9 and 10 showed weak α-glucosidase inhibition with the IC(50) values of 0.50, 0.66, 0.058, 0.20, 0.32, 0.036, 0.026 and 0.37 mM, respectively. MDPI 2018-10-01 /pmc/articles/PMC6213923/ /pubmed/30275406 http://dx.doi.org/10.3390/md16100363 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Yanchao
Wang, Cong
Liu, Haishan
Zhu, Guoliang
Fu, Peng
Wang, Liping
Zhu, Weiming
Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum
title Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum
title_full Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum
title_fullStr Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum
title_full_unstemmed Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum
title_short Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum
title_sort meroterpenoids and isocoumarinoids from a myrothecium fungus associated with apocynum venetum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213923/
https://www.ncbi.nlm.nih.gov/pubmed/30275406
http://dx.doi.org/10.3390/md16100363
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