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MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner

Non-native ligands for growth factor receptors with distinct chemical properties and different biological activities have the potential to become therapeutic applications. We previously generated MET/hepatocyte growth factor (HGF) receptor agonists using bivalent macrocyclic peptides. The highest ME...

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Detalles Bibliográficos
Autores principales:	Miao, Wenyu, Sakai, Katsuya, Imamura, Ryu, Ito, Kenichiro, Suga, Hiroaki, Sakuma, Tetsushi, Yamamoto, Takashi, Matsumoto, Kunio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213957/ https://www.ncbi.nlm.nih.gov/pubmed/30322054 http://dx.doi.org/10.3390/ijms19103141

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