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Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host

Herpes simplex virus type 1 (HSV-1) is the most common virus, with an estimated infection rate of 60–95% among the adult population. Once infected, HSV-1 can remain latent in the host for a lifetime and be reactivated in patients with a compromised immune system. Reactivation of latent HSV-1 can als...

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Autores principales: Li, Wen, Wang, Xiao-Hua, Luo, Zhuo, Liu, Li-Fang, Yan, Chang, Yan, Chang-Yu, Chen, Guo-Dong, Gao, Hao, Duan, Wen-Jun, Kurihara, Hiroshi, Li, Yi-Fang, He, Rong-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213986/
https://www.ncbi.nlm.nih.gov/pubmed/30347851
http://dx.doi.org/10.3390/ijms19103266
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author Li, Wen
Wang, Xiao-Hua
Luo, Zhuo
Liu, Li-Fang
Yan, Chang
Yan, Chang-Yu
Chen, Guo-Dong
Gao, Hao
Duan, Wen-Jun
Kurihara, Hiroshi
Li, Yi-Fang
He, Rong-Rong
author_facet Li, Wen
Wang, Xiao-Hua
Luo, Zhuo
Liu, Li-Fang
Yan, Chang
Yan, Chang-Yu
Chen, Guo-Dong
Gao, Hao
Duan, Wen-Jun
Kurihara, Hiroshi
Li, Yi-Fang
He, Rong-Rong
author_sort Li, Wen
collection PubMed
description Herpes simplex virus type 1 (HSV-1) is the most common virus, with an estimated infection rate of 60–95% among the adult population. Once infected, HSV-1 can remain latent in the host for a lifetime and be reactivated in patients with a compromised immune system. Reactivation of latent HSV-1 can also be achieved by other stimuli. Though acyclovir (ACV) is a classic drug for HSV-1 infection, ACV-resistant strains have been found in immune-compromised patients and drug toxicity has also been commonly reported. Therefore, there is an urge to search for new anti-HSV-1 agents. Natural products with potential anti-HSV-1 activity have the advantages of minimal side effects, reduced toxicity, and they exert their effect by various mechanisms. This paper will not only provide a reference for the safe dose of these agents if they are to be used in humans, referring to the interrelated data obtained from in vitro experiments, but also introduce the main pharmacodynamic mechanisms of traditional Chinese medicine (TCM) against HSV-1. Taken together, TCM functions as a potential source for HSV-1 therapy by direct (blocking viral attachment/absorption/penetration/replication) or indirect (reducing the susceptibility to HSV-1 or regulating autophagy) antiviral activities. The potential of these active components in the development of anti-HSV-1 drugs will also be described.
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spelling pubmed-62139862018-11-14 Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host Li, Wen Wang, Xiao-Hua Luo, Zhuo Liu, Li-Fang Yan, Chang Yan, Chang-Yu Chen, Guo-Dong Gao, Hao Duan, Wen-Jun Kurihara, Hiroshi Li, Yi-Fang He, Rong-Rong Int J Mol Sci Review Herpes simplex virus type 1 (HSV-1) is the most common virus, with an estimated infection rate of 60–95% among the adult population. Once infected, HSV-1 can remain latent in the host for a lifetime and be reactivated in patients with a compromised immune system. Reactivation of latent HSV-1 can also be achieved by other stimuli. Though acyclovir (ACV) is a classic drug for HSV-1 infection, ACV-resistant strains have been found in immune-compromised patients and drug toxicity has also been commonly reported. Therefore, there is an urge to search for new anti-HSV-1 agents. Natural products with potential anti-HSV-1 activity have the advantages of minimal side effects, reduced toxicity, and they exert their effect by various mechanisms. This paper will not only provide a reference for the safe dose of these agents if they are to be used in humans, referring to the interrelated data obtained from in vitro experiments, but also introduce the main pharmacodynamic mechanisms of traditional Chinese medicine (TCM) against HSV-1. Taken together, TCM functions as a potential source for HSV-1 therapy by direct (blocking viral attachment/absorption/penetration/replication) or indirect (reducing the susceptibility to HSV-1 or regulating autophagy) antiviral activities. The potential of these active components in the development of anti-HSV-1 drugs will also be described. MDPI 2018-10-20 /pmc/articles/PMC6213986/ /pubmed/30347851 http://dx.doi.org/10.3390/ijms19103266 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Wen
Wang, Xiao-Hua
Luo, Zhuo
Liu, Li-Fang
Yan, Chang
Yan, Chang-Yu
Chen, Guo-Dong
Gao, Hao
Duan, Wen-Jun
Kurihara, Hiroshi
Li, Yi-Fang
He, Rong-Rong
Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
title Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
title_full Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
title_fullStr Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
title_full_unstemmed Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
title_short Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
title_sort traditional chinese medicine as a potential source for hsv-1 therapy by acting on virus or the susceptibility of host
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213986/
https://www.ncbi.nlm.nih.gov/pubmed/30347851
http://dx.doi.org/10.3390/ijms19103266
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