Cargando…
Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
Herpes simplex virus type 1 (HSV-1) is the most common virus, with an estimated infection rate of 60–95% among the adult population. Once infected, HSV-1 can remain latent in the host for a lifetime and be reactivated in patients with a compromised immune system. Reactivation of latent HSV-1 can als...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213986/ https://www.ncbi.nlm.nih.gov/pubmed/30347851 http://dx.doi.org/10.3390/ijms19103266 |
_version_ | 1783367903459934208 |
---|---|
author | Li, Wen Wang, Xiao-Hua Luo, Zhuo Liu, Li-Fang Yan, Chang Yan, Chang-Yu Chen, Guo-Dong Gao, Hao Duan, Wen-Jun Kurihara, Hiroshi Li, Yi-Fang He, Rong-Rong |
author_facet | Li, Wen Wang, Xiao-Hua Luo, Zhuo Liu, Li-Fang Yan, Chang Yan, Chang-Yu Chen, Guo-Dong Gao, Hao Duan, Wen-Jun Kurihara, Hiroshi Li, Yi-Fang He, Rong-Rong |
author_sort | Li, Wen |
collection | PubMed |
description | Herpes simplex virus type 1 (HSV-1) is the most common virus, with an estimated infection rate of 60–95% among the adult population. Once infected, HSV-1 can remain latent in the host for a lifetime and be reactivated in patients with a compromised immune system. Reactivation of latent HSV-1 can also be achieved by other stimuli. Though acyclovir (ACV) is a classic drug for HSV-1 infection, ACV-resistant strains have been found in immune-compromised patients and drug toxicity has also been commonly reported. Therefore, there is an urge to search for new anti-HSV-1 agents. Natural products with potential anti-HSV-1 activity have the advantages of minimal side effects, reduced toxicity, and they exert their effect by various mechanisms. This paper will not only provide a reference for the safe dose of these agents if they are to be used in humans, referring to the interrelated data obtained from in vitro experiments, but also introduce the main pharmacodynamic mechanisms of traditional Chinese medicine (TCM) against HSV-1. Taken together, TCM functions as a potential source for HSV-1 therapy by direct (blocking viral attachment/absorption/penetration/replication) or indirect (reducing the susceptibility to HSV-1 or regulating autophagy) antiviral activities. The potential of these active components in the development of anti-HSV-1 drugs will also be described. |
format | Online Article Text |
id | pubmed-6213986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62139862018-11-14 Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host Li, Wen Wang, Xiao-Hua Luo, Zhuo Liu, Li-Fang Yan, Chang Yan, Chang-Yu Chen, Guo-Dong Gao, Hao Duan, Wen-Jun Kurihara, Hiroshi Li, Yi-Fang He, Rong-Rong Int J Mol Sci Review Herpes simplex virus type 1 (HSV-1) is the most common virus, with an estimated infection rate of 60–95% among the adult population. Once infected, HSV-1 can remain latent in the host for a lifetime and be reactivated in patients with a compromised immune system. Reactivation of latent HSV-1 can also be achieved by other stimuli. Though acyclovir (ACV) is a classic drug for HSV-1 infection, ACV-resistant strains have been found in immune-compromised patients and drug toxicity has also been commonly reported. Therefore, there is an urge to search for new anti-HSV-1 agents. Natural products with potential anti-HSV-1 activity have the advantages of minimal side effects, reduced toxicity, and they exert their effect by various mechanisms. This paper will not only provide a reference for the safe dose of these agents if they are to be used in humans, referring to the interrelated data obtained from in vitro experiments, but also introduce the main pharmacodynamic mechanisms of traditional Chinese medicine (TCM) against HSV-1. Taken together, TCM functions as a potential source for HSV-1 therapy by direct (blocking viral attachment/absorption/penetration/replication) or indirect (reducing the susceptibility to HSV-1 or regulating autophagy) antiviral activities. The potential of these active components in the development of anti-HSV-1 drugs will also be described. MDPI 2018-10-20 /pmc/articles/PMC6213986/ /pubmed/30347851 http://dx.doi.org/10.3390/ijms19103266 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Wen Wang, Xiao-Hua Luo, Zhuo Liu, Li-Fang Yan, Chang Yan, Chang-Yu Chen, Guo-Dong Gao, Hao Duan, Wen-Jun Kurihara, Hiroshi Li, Yi-Fang He, Rong-Rong Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host |
title | Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host |
title_full | Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host |
title_fullStr | Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host |
title_full_unstemmed | Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host |
title_short | Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host |
title_sort | traditional chinese medicine as a potential source for hsv-1 therapy by acting on virus or the susceptibility of host |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213986/ https://www.ncbi.nlm.nih.gov/pubmed/30347851 http://dx.doi.org/10.3390/ijms19103266 |
work_keys_str_mv | AT liwen traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT wangxiaohua traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT luozhuo traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT liulifang traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT yanchang traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT yanchangyu traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT chenguodong traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT gaohao traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT duanwenjun traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT kuriharahiroshi traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT liyifang traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost AT herongrong traditionalchinesemedicineasapotentialsourceforhsv1therapybyactingonvirusorthesusceptibilityofhost |