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Homology Model and Docking-Based Virtual Screening for Ligands of Human Dyskerin as New Inhibitors of Telomerase for Cancer Treatment

Immortality is one of the main features of cancer cells. Tumor cells have an unlimited replicative potential, principally due to the holoenzyme telomerase. Telomerase is composed mainly by dyskerin (DKC1), a catalytic retrotranscriptase (hTERT) and an RNA template (hTR). The aim of this work is to d...

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Detalles Bibliográficos
Autores principales:	Armando, Romina Gabriela, Mengual Gómez, Diego Luis, Juritz, Ezequiel Ivan, Lorenzano Menna, Pablo, Gomez, Daniel Eduardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214037/ https://www.ncbi.nlm.nih.gov/pubmed/30340325 http://dx.doi.org/10.3390/ijms19103216

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