Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?

Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial dysfunction, distal pulmonary vessel remodeling, and inflammation, which could all depend on ion channel activities (K(+), C...

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Autores principales: Lambert, Mélanie, Capuano, Véronique, Olschewski, Andrea, Sabourin, Jessica, Nagaraj, Chandran, Girerd, Barbara, Weatherald, Jason, Humbert, Marc, Antigny, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214085/
https://www.ncbi.nlm.nih.gov/pubmed/30322215
http://dx.doi.org/10.3390/ijms19103162
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author Lambert, Mélanie
Capuano, Véronique
Olschewski, Andrea
Sabourin, Jessica
Nagaraj, Chandran
Girerd, Barbara
Weatherald, Jason
Humbert, Marc
Antigny, Fabrice
author_facet Lambert, Mélanie
Capuano, Véronique
Olschewski, Andrea
Sabourin, Jessica
Nagaraj, Chandran
Girerd, Barbara
Weatherald, Jason
Humbert, Marc
Antigny, Fabrice
author_sort Lambert, Mélanie
collection PubMed
description Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial dysfunction, distal pulmonary vessel remodeling, and inflammation, which could all depend on ion channel activities (K(+), Ca(2+), Na(+) and Cl(−)). This review focuses on ion channels in the pulmonary vasculature and discusses their pathophysiological contribution to PAH as well as their therapeutic potential in PAH.
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spelling pubmed-62140852018-11-14 Ion Channels in Pulmonary Hypertension: A Therapeutic Interest? Lambert, Mélanie Capuano, Véronique Olschewski, Andrea Sabourin, Jessica Nagaraj, Chandran Girerd, Barbara Weatherald, Jason Humbert, Marc Antigny, Fabrice Int J Mol Sci Review Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial dysfunction, distal pulmonary vessel remodeling, and inflammation, which could all depend on ion channel activities (K(+), Ca(2+), Na(+) and Cl(−)). This review focuses on ion channels in the pulmonary vasculature and discusses their pathophysiological contribution to PAH as well as their therapeutic potential in PAH. MDPI 2018-10-14 /pmc/articles/PMC6214085/ /pubmed/30322215 http://dx.doi.org/10.3390/ijms19103162 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lambert, Mélanie
Capuano, Véronique
Olschewski, Andrea
Sabourin, Jessica
Nagaraj, Chandran
Girerd, Barbara
Weatherald, Jason
Humbert, Marc
Antigny, Fabrice
Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?
title Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?
title_full Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?
title_fullStr Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?
title_full_unstemmed Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?
title_short Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?
title_sort ion channels in pulmonary hypertension: a therapeutic interest?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214085/
https://www.ncbi.nlm.nih.gov/pubmed/30322215
http://dx.doi.org/10.3390/ijms19103162
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