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Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling

Ontogeny of higher organisms as well the regulation of tissue homeostasis in adult individuals requires a fine-balanced interplay of regulating factors that individually trigger the fate of particular cells to either stay undifferentiated or to differentiate towards distinct tissue specific lineages...

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Detalles Bibliográficos
Autores principales: Schliermann, Anna, Nickel, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214098/
https://www.ncbi.nlm.nih.gov/pubmed/30340367
http://dx.doi.org/10.3390/ijms19103220
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author Schliermann, Anna
Nickel, Joachim
author_facet Schliermann, Anna
Nickel, Joachim
author_sort Schliermann, Anna
collection PubMed
description Ontogeny of higher organisms as well the regulation of tissue homeostasis in adult individuals requires a fine-balanced interplay of regulating factors that individually trigger the fate of particular cells to either stay undifferentiated or to differentiate towards distinct tissue specific lineages. In some cases, these factors act synergistically to promote certain cellular responses, whereas in other tissues the same factors antagonize each other. However, the molecular basis of this obvious dual signaling activity is still only poorly understood. Bone morphogenetic proteins (BMPs) and fibroblast growth factors (FGFs) are two major signal protein families that have a lot in common: They are both highly preserved between different species, involved in essential cellular functions, and their ligands vastly outnumber their receptors, making extensive signal regulation necessary. In this review we discuss where and how BMP and FGF signaling cross paths. The compiled data reflect that both factors synchronously act in many tissues, and that antagonism and synergism both exist in a context-dependent manner. Therefore, by challenging a generalization of the connection between these two pathways a new chapter in BMP FGF signaling research will be introduced.
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spelling pubmed-62140982018-11-14 Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling Schliermann, Anna Nickel, Joachim Int J Mol Sci Review Ontogeny of higher organisms as well the regulation of tissue homeostasis in adult individuals requires a fine-balanced interplay of regulating factors that individually trigger the fate of particular cells to either stay undifferentiated or to differentiate towards distinct tissue specific lineages. In some cases, these factors act synergistically to promote certain cellular responses, whereas in other tissues the same factors antagonize each other. However, the molecular basis of this obvious dual signaling activity is still only poorly understood. Bone morphogenetic proteins (BMPs) and fibroblast growth factors (FGFs) are two major signal protein families that have a lot in common: They are both highly preserved between different species, involved in essential cellular functions, and their ligands vastly outnumber their receptors, making extensive signal regulation necessary. In this review we discuss where and how BMP and FGF signaling cross paths. The compiled data reflect that both factors synchronously act in many tissues, and that antagonism and synergism both exist in a context-dependent manner. Therefore, by challenging a generalization of the connection between these two pathways a new chapter in BMP FGF signaling research will be introduced. MDPI 2018-10-18 /pmc/articles/PMC6214098/ /pubmed/30340367 http://dx.doi.org/10.3390/ijms19103220 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schliermann, Anna
Nickel, Joachim
Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling
title Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling
title_full Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling
title_fullStr Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling
title_full_unstemmed Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling
title_short Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling
title_sort unraveling the connection between fibroblast growth factor and bone morphogenetic protein signaling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214098/
https://www.ncbi.nlm.nih.gov/pubmed/30340367
http://dx.doi.org/10.3390/ijms19103220
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