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Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites

BACKGROUND AND OBJECTIVE: Severe alpha1 antitrypsin deficiency has been clearly associated with pulmonary emphysema, but its relationship with bronchial asthma remains controversial. Some deficient alpha 1 antitrypsin (AAT) genotypes seem to be associated with asthma development. The objective of th...

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Autores principales: Suárez-Lorenzo, I., de Castro, F. Rodríguez, Cruz-Niesvaara, D., Herrera-Ramos, E., Rodríguez-Gallego, C., Carrillo-Diaz, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214172/
https://www.ncbi.nlm.nih.gov/pubmed/30410723
http://dx.doi.org/10.1186/s13601-018-0231-x
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author Suárez-Lorenzo, I.
de Castro, F. Rodríguez
Cruz-Niesvaara, D.
Herrera-Ramos, E.
Rodríguez-Gallego, C.
Carrillo-Diaz, T.
author_facet Suárez-Lorenzo, I.
de Castro, F. Rodríguez
Cruz-Niesvaara, D.
Herrera-Ramos, E.
Rodríguez-Gallego, C.
Carrillo-Diaz, T.
author_sort Suárez-Lorenzo, I.
collection PubMed
description BACKGROUND AND OBJECTIVE: Severe alpha1 antitrypsin deficiency has been clearly associated with pulmonary emphysema, but its relationship with bronchial asthma remains controversial. Some deficient alpha 1 antitrypsin (AAT) genotypes seem to be associated with asthma development. The objective of this study was to analyze the distribution of AAT genotypes in asthmatic patients allergic to house dust mites (HDM), and to asses a possible association between these genotypes and severe asthma. METHODS: A cross-sectional cohort study of 648 patients with HDM allergic asthma was carried out. Demographic, clinical and analytical variables were collected. PI*S and PI*Z AAT deficient alleles of the SERPINA1 gene were assayed by real-time PCR. RESULTS: Asthma was intermittent in 253 patients and persistent in 395 patients (246 mild, 101 moderate and 48 severe). One hundred and forty-five asthmatic patients (22.4%) with at least one mutated allele (S or Z) were identified. No association between the different genotypes and asthma severity was found. No significant differences in all clinical and functional tests, as well as nasal eosinophils, IgA and IgE serum levels were observed. Peripheral eosinophils were significantly lower in patients with the PI*MS genotype (p = 0.0228). Neither association between deficient AAT genotypes or serum ATT deficiency (AATD) and development of severe asthma, or correlation between ATT levels and FEV1 was observed. CONCLUSION: In conclusion, the distribution of AAT genotypes in HDM allergic asthmatic patients did not differ from those found in Spanish population. Neither severe ATTD or deficient AAT genotypes appear to confer different clinical expression of asthma.
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spelling pubmed-62141722018-11-08 Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites Suárez-Lorenzo, I. de Castro, F. Rodríguez Cruz-Niesvaara, D. Herrera-Ramos, E. Rodríguez-Gallego, C. Carrillo-Diaz, T. Clin Transl Allergy Research BACKGROUND AND OBJECTIVE: Severe alpha1 antitrypsin deficiency has been clearly associated with pulmonary emphysema, but its relationship with bronchial asthma remains controversial. Some deficient alpha 1 antitrypsin (AAT) genotypes seem to be associated with asthma development. The objective of this study was to analyze the distribution of AAT genotypes in asthmatic patients allergic to house dust mites (HDM), and to asses a possible association between these genotypes and severe asthma. METHODS: A cross-sectional cohort study of 648 patients with HDM allergic asthma was carried out. Demographic, clinical and analytical variables were collected. PI*S and PI*Z AAT deficient alleles of the SERPINA1 gene were assayed by real-time PCR. RESULTS: Asthma was intermittent in 253 patients and persistent in 395 patients (246 mild, 101 moderate and 48 severe). One hundred and forty-five asthmatic patients (22.4%) with at least one mutated allele (S or Z) were identified. No association between the different genotypes and asthma severity was found. No significant differences in all clinical and functional tests, as well as nasal eosinophils, IgA and IgE serum levels were observed. Peripheral eosinophils were significantly lower in patients with the PI*MS genotype (p = 0.0228). Neither association between deficient AAT genotypes or serum ATT deficiency (AATD) and development of severe asthma, or correlation between ATT levels and FEV1 was observed. CONCLUSION: In conclusion, the distribution of AAT genotypes in HDM allergic asthmatic patients did not differ from those found in Spanish population. Neither severe ATTD or deficient AAT genotypes appear to confer different clinical expression of asthma. BioMed Central 2018-11-02 /pmc/articles/PMC6214172/ /pubmed/30410723 http://dx.doi.org/10.1186/s13601-018-0231-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Suárez-Lorenzo, I.
de Castro, F. Rodríguez
Cruz-Niesvaara, D.
Herrera-Ramos, E.
Rodríguez-Gallego, C.
Carrillo-Diaz, T.
Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
title Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
title_full Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
title_fullStr Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
title_full_unstemmed Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
title_short Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
title_sort alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214172/
https://www.ncbi.nlm.nih.gov/pubmed/30410723
http://dx.doi.org/10.1186/s13601-018-0231-x
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