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Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation

BACKGROUND: Peritumoral inflammation—a response mainly involving polimorphonuclear neutrophils—has traditionally been thought protumoral in its effects. In recent years, however, a number of studies have indicated that it may play an important antitumoral role. This discrepancy has been difficult to...

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Autores principales: Brú, Antonio, Gómez-Castro, David, Vila, Luis, Brú, Isabel, Souto, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214501/
https://www.ncbi.nlm.nih.gov/pubmed/30388111
http://dx.doi.org/10.1371/journal.pone.0202823
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author Brú, Antonio
Gómez-Castro, David
Vila, Luis
Brú, Isabel
Souto, Juan Carlos
author_facet Brú, Antonio
Gómez-Castro, David
Vila, Luis
Brú, Isabel
Souto, Juan Carlos
author_sort Brú, Antonio
collection PubMed
description BACKGROUND: Peritumoral inflammation—a response mainly involving polimorphonuclear neutrophils—has traditionally been thought protumoral in its effects. In recent years, however, a number of studies have indicated that it may play an important antitumoral role. This discrepancy has been difficult to explain. METHODS AND FINDINGS: This work describes a tool for simulating tumor growth that obeys the universal model of tumor growth dynamics, and shows through its use that low intensity peritumoral inflammation exerts a protumoral effect, while high intensity inflammation exerts a potent antitumoral effect. Indeed, the simulation results obtained indicate that a sufficiently strong antitumoral effect can reverse tumor growth, as has been suggested several times in the clinical literature. CONCLUSIONS: The present result indicate that an ‘immunological threshold’ must exist, marking the boundary between states in which peritumoral inflammation is either harmful or beneficial. These findings lend support to the idea that stimulating intense peritumoral inflammation could be used as a treatment against solid tumors.
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spelling pubmed-62145012018-11-19 Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation Brú, Antonio Gómez-Castro, David Vila, Luis Brú, Isabel Souto, Juan Carlos PLoS One Research Article BACKGROUND: Peritumoral inflammation—a response mainly involving polimorphonuclear neutrophils—has traditionally been thought protumoral in its effects. In recent years, however, a number of studies have indicated that it may play an important antitumoral role. This discrepancy has been difficult to explain. METHODS AND FINDINGS: This work describes a tool for simulating tumor growth that obeys the universal model of tumor growth dynamics, and shows through its use that low intensity peritumoral inflammation exerts a protumoral effect, while high intensity inflammation exerts a potent antitumoral effect. Indeed, the simulation results obtained indicate that a sufficiently strong antitumoral effect can reverse tumor growth, as has been suggested several times in the clinical literature. CONCLUSIONS: The present result indicate that an ‘immunological threshold’ must exist, marking the boundary between states in which peritumoral inflammation is either harmful or beneficial. These findings lend support to the idea that stimulating intense peritumoral inflammation could be used as a treatment against solid tumors. Public Library of Science 2018-11-02 /pmc/articles/PMC6214501/ /pubmed/30388111 http://dx.doi.org/10.1371/journal.pone.0202823 Text en © 2018 Brú et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Brú, Antonio
Gómez-Castro, David
Vila, Luis
Brú, Isabel
Souto, Juan Carlos
Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation
title Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation
title_full Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation
title_fullStr Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation
title_full_unstemmed Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation
title_short Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation
title_sort study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214501/
https://www.ncbi.nlm.nih.gov/pubmed/30388111
http://dx.doi.org/10.1371/journal.pone.0202823
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