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Structural and functional brain abnormalities in drug-naive, first-episode, and chronic patients with schizophrenia: a multimodal MRI study

BACKGROUND: Structural and functional brain abnormalities in schizophrenia (SZ) have been widely reported. However, a few studies have investigated both structural and functional characteristics in SZ patients at different stages to understand the neuropathology of SZ. METHODS: In this study, we rec...

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Autores principales: Wu, Fengchun, Zhang, Yue, Yang, Yongzhe, Lu, Xiaobing, Fang, Ziyan, Huang, Jianwei, Kong, Lingyin, Chen, Jun, Ning, Yuping, Li, Xiaobo, Wu, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214581/
https://www.ncbi.nlm.nih.gov/pubmed/30464473
http://dx.doi.org/10.2147/NDT.S174356
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author Wu, Fengchun
Zhang, Yue
Yang, Yongzhe
Lu, Xiaobing
Fang, Ziyan
Huang, Jianwei
Kong, Lingyin
Chen, Jun
Ning, Yuping
Li, Xiaobo
Wu, Kai
author_facet Wu, Fengchun
Zhang, Yue
Yang, Yongzhe
Lu, Xiaobing
Fang, Ziyan
Huang, Jianwei
Kong, Lingyin
Chen, Jun
Ning, Yuping
Li, Xiaobo
Wu, Kai
author_sort Wu, Fengchun
collection PubMed
description BACKGROUND: Structural and functional brain abnormalities in schizophrenia (SZ) have been widely reported. However, a few studies have investigated both structural and functional characteristics in SZ patients at different stages to understand the neuropathology of SZ. METHODS: In this study, we recruited 44 first-episode drug-naive SZ (FESZ) patients, 44 medicated chronic SZ (CSZ) patients, and 56 normal controls (NCs) and acquired their structural and resting-state functional magnetic resonance imaging (MRI). We then made group comparisons on structural and functional characteristics, including regional gray matter volume (GMV), regional homogeneity, amplitude of low-frequency fluctuation, and degree centrality. A linear support vector machine (SVM) combined with a recursive feature elimination (RFE) algorithm was implemented to discriminate three groups. RESULTS: Our results indicated that the regional GMV was significantly decreased in patients compared with that in NCs; CSZ patients have more diffused GMV decreases primarily involved in the frontal and temporal lobes when compared with FESZ patients. Both FESZ and CSZ patients showed significant functional alterations compared with NCs; when compared with FESZ patients, CSZ patients showed significant reductions in functional characteristics in several brain regions associated with auditory, visual processing, and sensorimotor functions. Moreover, a linear SVM combined with a RFE algorithm was implemented to discriminate three groups. The accuracies of the three classifiers were 79.80%, 83.16%, and 81.71%, respectively. The performance of classifiers in this study with multimodal MRI was better than that of previous discriminative analyses of SZ patients with single-modal MRI. CONCLUSION: Our findings bring new insights into the understanding of the neuropathology of SZ and contribute to stage-specific biomarkers in diagnosis and interventions of SZ.
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spelling pubmed-62145812018-11-21 Structural and functional brain abnormalities in drug-naive, first-episode, and chronic patients with schizophrenia: a multimodal MRI study Wu, Fengchun Zhang, Yue Yang, Yongzhe Lu, Xiaobing Fang, Ziyan Huang, Jianwei Kong, Lingyin Chen, Jun Ning, Yuping Li, Xiaobo Wu, Kai Neuropsychiatr Dis Treat Original Research BACKGROUND: Structural and functional brain abnormalities in schizophrenia (SZ) have been widely reported. However, a few studies have investigated both structural and functional characteristics in SZ patients at different stages to understand the neuropathology of SZ. METHODS: In this study, we recruited 44 first-episode drug-naive SZ (FESZ) patients, 44 medicated chronic SZ (CSZ) patients, and 56 normal controls (NCs) and acquired their structural and resting-state functional magnetic resonance imaging (MRI). We then made group comparisons on structural and functional characteristics, including regional gray matter volume (GMV), regional homogeneity, amplitude of low-frequency fluctuation, and degree centrality. A linear support vector machine (SVM) combined with a recursive feature elimination (RFE) algorithm was implemented to discriminate three groups. RESULTS: Our results indicated that the regional GMV was significantly decreased in patients compared with that in NCs; CSZ patients have more diffused GMV decreases primarily involved in the frontal and temporal lobes when compared with FESZ patients. Both FESZ and CSZ patients showed significant functional alterations compared with NCs; when compared with FESZ patients, CSZ patients showed significant reductions in functional characteristics in several brain regions associated with auditory, visual processing, and sensorimotor functions. Moreover, a linear SVM combined with a RFE algorithm was implemented to discriminate three groups. The accuracies of the three classifiers were 79.80%, 83.16%, and 81.71%, respectively. The performance of classifiers in this study with multimodal MRI was better than that of previous discriminative analyses of SZ patients with single-modal MRI. CONCLUSION: Our findings bring new insights into the understanding of the neuropathology of SZ and contribute to stage-specific biomarkers in diagnosis and interventions of SZ. Dove Medical Press 2018-10-30 /pmc/articles/PMC6214581/ /pubmed/30464473 http://dx.doi.org/10.2147/NDT.S174356 Text en © 2018 Wu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Wu, Fengchun
Zhang, Yue
Yang, Yongzhe
Lu, Xiaobing
Fang, Ziyan
Huang, Jianwei
Kong, Lingyin
Chen, Jun
Ning, Yuping
Li, Xiaobo
Wu, Kai
Structural and functional brain abnormalities in drug-naive, first-episode, and chronic patients with schizophrenia: a multimodal MRI study
title Structural and functional brain abnormalities in drug-naive, first-episode, and chronic patients with schizophrenia: a multimodal MRI study
title_full Structural and functional brain abnormalities in drug-naive, first-episode, and chronic patients with schizophrenia: a multimodal MRI study
title_fullStr Structural and functional brain abnormalities in drug-naive, first-episode, and chronic patients with schizophrenia: a multimodal MRI study
title_full_unstemmed Structural and functional brain abnormalities in drug-naive, first-episode, and chronic patients with schizophrenia: a multimodal MRI study
title_short Structural and functional brain abnormalities in drug-naive, first-episode, and chronic patients with schizophrenia: a multimodal MRI study
title_sort structural and functional brain abnormalities in drug-naive, first-episode, and chronic patients with schizophrenia: a multimodal mri study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214581/
https://www.ncbi.nlm.nih.gov/pubmed/30464473
http://dx.doi.org/10.2147/NDT.S174356
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