Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

The light chains (KLCs) of the heterotetrameric microtubule motor kinesin-1, that bind to cargo adaptor proteins and regulate its activity, have a capacity to recognize short peptides via their tetratricopeptide repeat domains (KLC(TPR)). Here, using X-ray crystallography, we show how kinesin-1 reco...

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Detalles Bibliográficos
Autores principales: Pernigo, Stefano, Chegkazi, Magda S, Yip, Yan Y, Treacy, Conor, Glorani, Giulia, Hansen, Kjetil, Politis, Argyris, Bui, Soi, Dodding, Mark P, Steiner, Roberto A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214655/
https://www.ncbi.nlm.nih.gov/pubmed/30320553
http://dx.doi.org/10.7554/eLife.38362

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