Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension

Integrins are conformationally flexible cell surface receptors that survey the extracellular environment for their cognate ligands. Interactions with ligands are thought to be linked to global structural rearrangements involving transitions between bent, extended-closed and -open forms. Thus far, st...

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Detalles Bibliográficos
Autores principales: Cormier, Anthony, Campbell, Melody G., Ito, Saburo, Wu, Shenping, Lou, Jianlong, Marks, James, Baron, Jody, Nishimura, Stephen L., Cheng, Yifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214843/
https://www.ncbi.nlm.nih.gov/pubmed/30061598
http://dx.doi.org/10.1038/s41594-018-0093-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214843/
https://www.ncbi.nlm.nih.gov/pubmed/30061598
http://dx.doi.org/10.1038/s41594-018-0093-x

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