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Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension
Integrins are conformationally flexible cell surface receptors that survey the extracellular environment for their cognate ligands. Interactions with ligands are thought to be linked to global structural rearrangements involving transitions between bent, extended-closed and -open forms. Thus far, st...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214843/ https://www.ncbi.nlm.nih.gov/pubmed/30061598 http://dx.doi.org/10.1038/s41594-018-0093-x |