Extracellular and ER-stored Ca(2+) contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells

The anti-apoptotic protein Bcl-2 is upregulated in several cancers, including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL). In a subset of these cancer cells, Bcl-2 blocks Ca(2+)-mediated apoptosis by suppressing the function of inositol 1,4,5-trisphosphate (IP(3)) re...

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Detalles Bibliográficos
Autores principales: Bittremieux, Mart, La Rovere, Rita M., Schuermans, Marleen, Luyten, Tomas, Mikoshiba, Katsuhiko, Vangheluwe, Peter, Parys, Jan B., Bultynck, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214954/
https://www.ncbi.nlm.nih.gov/pubmed/30416758
http://dx.doi.org/10.1038/s41420-018-0118-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214954/
https://www.ncbi.nlm.nih.gov/pubmed/30416758
http://dx.doi.org/10.1038/s41420-018-0118-6

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