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Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex
Diverse γ-aminobutyric acid (GABA)-ergic interneurons provide different modes of inhibition to support circuit operation in the neocortex. However, the cellular and molecular mechanisms underlying the systematic generation of assorted neocortical interneurons remain largely unclear. Here we show tha...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214958/ https://www.ncbi.nlm.nih.gov/pubmed/30389944 http://dx.doi.org/10.1038/s41467-018-07055-7 |
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author | Sultan, Khadeejah T. Liu, Wenying Angela Li, Zhao-Lu Shen, Zhongfu Li, Zhizhong Zhang, Xin-Jun Dean, Owen Ma, Jian Shi, Song-Hai |
author_facet | Sultan, Khadeejah T. Liu, Wenying Angela Li, Zhao-Lu Shen, Zhongfu Li, Zhizhong Zhang, Xin-Jun Dean, Owen Ma, Jian Shi, Song-Hai |
author_sort | Sultan, Khadeejah T. |
collection | PubMed |
description | Diverse γ-aminobutyric acid (GABA)-ergic interneurons provide different modes of inhibition to support circuit operation in the neocortex. However, the cellular and molecular mechanisms underlying the systematic generation of assorted neocortical interneurons remain largely unclear. Here we show that NKX2.1-expressing radial glial progenitors (RGPs) in the mouse embryonic ventral telencephalon divide progressively to generate distinct groups of interneurons, which occupy the neocortex in a time-dependent, early inside-out and late outside-in, manner. Notably, the late-born chandelier cells, one of the morphologically and physiologically highly distinguishable GABAergic interneurons, arise reliably from continuously dividing RGPs that produce non-chandelier cells initially. Selective removal of Partition defective 3, an evolutionarily conserved cell polarity protein, impairs RGP asymmetric cell division, resulting in premature depletion of RGPs towards the late embryonic stages and a consequent loss of chandelier cells. These results suggest that consecutive asymmetric divisions of multipotent RGPs generate diverse neocortical interneurons in a progressive manner. |
format | Online Article Text |
id | pubmed-6214958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62149582018-11-05 Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex Sultan, Khadeejah T. Liu, Wenying Angela Li, Zhao-Lu Shen, Zhongfu Li, Zhizhong Zhang, Xin-Jun Dean, Owen Ma, Jian Shi, Song-Hai Nat Commun Article Diverse γ-aminobutyric acid (GABA)-ergic interneurons provide different modes of inhibition to support circuit operation in the neocortex. However, the cellular and molecular mechanisms underlying the systematic generation of assorted neocortical interneurons remain largely unclear. Here we show that NKX2.1-expressing radial glial progenitors (RGPs) in the mouse embryonic ventral telencephalon divide progressively to generate distinct groups of interneurons, which occupy the neocortex in a time-dependent, early inside-out and late outside-in, manner. Notably, the late-born chandelier cells, one of the morphologically and physiologically highly distinguishable GABAergic interneurons, arise reliably from continuously dividing RGPs that produce non-chandelier cells initially. Selective removal of Partition defective 3, an evolutionarily conserved cell polarity protein, impairs RGP asymmetric cell division, resulting in premature depletion of RGPs towards the late embryonic stages and a consequent loss of chandelier cells. These results suggest that consecutive asymmetric divisions of multipotent RGPs generate diverse neocortical interneurons in a progressive manner. Nature Publishing Group UK 2018-11-02 /pmc/articles/PMC6214958/ /pubmed/30389944 http://dx.doi.org/10.1038/s41467-018-07055-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Sultan, Khadeejah T. Liu, Wenying Angela Li, Zhao-Lu Shen, Zhongfu Li, Zhizhong Zhang, Xin-Jun Dean, Owen Ma, Jian Shi, Song-Hai Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex |
title | Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex |
title_full | Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex |
title_fullStr | Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex |
title_full_unstemmed | Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex |
title_short | Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex |
title_sort | progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214958/ https://www.ncbi.nlm.nih.gov/pubmed/30389944 http://dx.doi.org/10.1038/s41467-018-07055-7 |
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