Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Activation of platelet-derived growth factor receptor alpha (PDGFRA) by genomic aberrations contributes to tumor progression in several tumor types. In this study, we characterize 16 novel PDGFRA mutations identified from different tumor types and identify three previously uncharacterized activating...

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Detalles Bibliográficos
Autores principales: Ip, Carman K. M., Ng, Patrick K. S., Jeong, Kang Jin, Shao, S. H., Ju, Zhenlin, Leonard, P. G., Hua, Xu, Vellano, Christopher P., Woessner, Richard, Sahni, Nidhi, Scott, Kenneth L., Mills, Gordon B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214970/
https://www.ncbi.nlm.nih.gov/pubmed/30389923
http://dx.doi.org/10.1038/s41467-018-06949-w

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