Early heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2(−/−) mice

Multi drug resistance protein 2 knockout mice (Mdr2(−/−)) are a mouse model of chronic liver inflammation and inflammation-induced tumour development. Here we investigated the kinetics of early heme oxygenase 1 (HO-1) induction on inflammation, tumour development, and DNA damage in Mdr2(−/−) mice. H...

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Detalles Bibliográficos
Autores principales: Barikbin, Roja, Berkhout, Laura, Bolik, Julia, Schmidt-Arras, Dirk, Ernst, Thomas, Ittrich, Harald, Adam, Gerhard, Parplys, Ann, Casar, Christian, Krech, Till, Karimi, Khalil, Sass, Gabriele, Tiegs, Gisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214975/
https://www.ncbi.nlm.nih.gov/pubmed/30389969
http://dx.doi.org/10.1038/s41598-018-33233-0

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