Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer

Lung adenocarcinomas (LUADs) with mutations in the K-ras oncogene display dismal prognosis. Proinflammatory and immunomodulatory events that drive development of K-ras mutant LUAD are poorly understood. Here, we develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout (LR/Stat3(Δ/Δ...

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Detalles Bibliográficos
Autores principales: Caetano, Mauricio S., Hassane, Maya, Van, Hieu T., Bugarin, Emmanuel, Cumpian, Amber M., McDowell, Christina L., Cavazos, Carolina Gonzalez, Zhang, Huiyuan, Deng, Shanshan, Diao, Lixia, Wang, Jing, Evans, Scott E., Behrens, Carmen, Wistuba, Ignacio I., Fuqua, Susan A. W., Lin, Huang, Stabile, Laura P., Watowich, Stephanie S., Kadara, Humam, Moghaddam, Seyed Javad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214980/
https://www.ncbi.nlm.nih.gov/pubmed/30389925
http://dx.doi.org/10.1038/s41467-018-07042-y

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