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TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells

CRISPR/Cas9 mediated gene editing of patient-derived hematopoietic stem and progenitor cells (HSPCs) ex vivo followed by autologous transplantation of the edited HSPCs back to the patient can provide a potential cure for monogenic blood disorders such as β-hemoglobinopathies. One challenge for this...

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Detalles Bibliográficos
Autores principales:	Yen, Jonathan, Fiorino, Michael, Liu, Yi, Paula, Steve, Clarkson, Scott, Quinn, Lisa, Tschantz, William R., Klock, Heath, Guo, Ning, Russ, Carsten, Yu, Vionnie W. C., Mickanin, Craig, Stevenson, Susan C., Lee, Cameron, Yang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214993/ https://www.ncbi.nlm.nih.gov/pubmed/30389991 http://dx.doi.org/10.1038/s41598-018-34601-6

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