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Effect of Statins on Renal Function in Chronic Kidney Disease Patients
Dyslipidemia is associated with glomerular injury. However, the effect of statins on chronic kidney disease (CKD) progression remains controversial. We aimed to investigate the efficacy of statins for renal protection in patients with CKD. The retrospective cohort study comprised 3441 patients diagn...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215008/ https://www.ncbi.nlm.nih.gov/pubmed/30390007 http://dx.doi.org/10.1038/s41598-018-34632-z |
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author | Hu, Ping-Jen Wu, Mei-Yi Lin, Tsu-Chen Chen, Tzu-Ting Wu, Yun-Chun Su, Sui-Lung Lu, Kuo-Cheng Chen, Jin-Shuen Sung, Fung-Chang Lee, Chien-Te Yang, Yu Hwang, Shang-Jyh Wang, Ming-Cheng Hsu, Yung-Ho Chiou, Hung-Yi Wong, Chung-Shun Lin, Yuh-Feng |
author_facet | Hu, Ping-Jen Wu, Mei-Yi Lin, Tsu-Chen Chen, Tzu-Ting Wu, Yun-Chun Su, Sui-Lung Lu, Kuo-Cheng Chen, Jin-Shuen Sung, Fung-Chang Lee, Chien-Te Yang, Yu Hwang, Shang-Jyh Wang, Ming-Cheng Hsu, Yung-Ho Chiou, Hung-Yi Wong, Chung-Shun Lin, Yuh-Feng |
author_sort | Hu, Ping-Jen |
collection | PubMed |
description | Dyslipidemia is associated with glomerular injury. However, the effect of statins on chronic kidney disease (CKD) progression remains controversial. We aimed to investigate the efficacy of statins for renal protection in patients with CKD. The retrospective cohort study comprised 3441 patients diagnosed with CKD in multiple medical centers. We divided the patients into two cohorts based on statin prescription, and compared proportions and risks of CKD progression events between the two groups. CKD progression event was defined as an average annual decline of eGFR >5 mL/min/1.73 m(2) or advancement to the dialysis stage. The result revealed that among all incident patients with CKD, 28.7% and 30.3% of the users and nonusers demonstrated CKD progression, respectively. The crude odds ratio (OR) of CKD progression was 0.93 [95% confidence interval (CI) 0.78–1.10]. After adjustment for baseline characteristics, the adjusted OR was 0.80 (95% CI 0.63–1.01). The sensitivity analysis results showed consistent OR for CKD progression, stratification by age, sex, Charlson score, and statins use within 1 year before index date. The effect of statins was significant in patients with CKD stage 3B-5 (OR 0.68, 95% CI 0.48–0.95), but not statistically significant in those with CKD stage 1–3A (OR 0.97, 95% CI 0.68–1.38). The effect of statins was significant in patients with proteinuria ≥1000 mg/day (OR 0.63, 95% CI 0.43–0.92), but not statistically significant in those with proteinuria <1000 mg/day (OR 1.02, 95% CI 0.74–1.41). |
format | Online Article Text |
id | pubmed-6215008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62150082018-11-06 Effect of Statins on Renal Function in Chronic Kidney Disease Patients Hu, Ping-Jen Wu, Mei-Yi Lin, Tsu-Chen Chen, Tzu-Ting Wu, Yun-Chun Su, Sui-Lung Lu, Kuo-Cheng Chen, Jin-Shuen Sung, Fung-Chang Lee, Chien-Te Yang, Yu Hwang, Shang-Jyh Wang, Ming-Cheng Hsu, Yung-Ho Chiou, Hung-Yi Wong, Chung-Shun Lin, Yuh-Feng Sci Rep Article Dyslipidemia is associated with glomerular injury. However, the effect of statins on chronic kidney disease (CKD) progression remains controversial. We aimed to investigate the efficacy of statins for renal protection in patients with CKD. The retrospective cohort study comprised 3441 patients diagnosed with CKD in multiple medical centers. We divided the patients into two cohorts based on statin prescription, and compared proportions and risks of CKD progression events between the two groups. CKD progression event was defined as an average annual decline of eGFR >5 mL/min/1.73 m(2) or advancement to the dialysis stage. The result revealed that among all incident patients with CKD, 28.7% and 30.3% of the users and nonusers demonstrated CKD progression, respectively. The crude odds ratio (OR) of CKD progression was 0.93 [95% confidence interval (CI) 0.78–1.10]. After adjustment for baseline characteristics, the adjusted OR was 0.80 (95% CI 0.63–1.01). The sensitivity analysis results showed consistent OR for CKD progression, stratification by age, sex, Charlson score, and statins use within 1 year before index date. The effect of statins was significant in patients with CKD stage 3B-5 (OR 0.68, 95% CI 0.48–0.95), but not statistically significant in those with CKD stage 1–3A (OR 0.97, 95% CI 0.68–1.38). The effect of statins was significant in patients with proteinuria ≥1000 mg/day (OR 0.63, 95% CI 0.43–0.92), but not statistically significant in those with proteinuria <1000 mg/day (OR 1.02, 95% CI 0.74–1.41). Nature Publishing Group UK 2018-11-02 /pmc/articles/PMC6215008/ /pubmed/30390007 http://dx.doi.org/10.1038/s41598-018-34632-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hu, Ping-Jen Wu, Mei-Yi Lin, Tsu-Chen Chen, Tzu-Ting Wu, Yun-Chun Su, Sui-Lung Lu, Kuo-Cheng Chen, Jin-Shuen Sung, Fung-Chang Lee, Chien-Te Yang, Yu Hwang, Shang-Jyh Wang, Ming-Cheng Hsu, Yung-Ho Chiou, Hung-Yi Wong, Chung-Shun Lin, Yuh-Feng Effect of Statins on Renal Function in Chronic Kidney Disease Patients |
title | Effect of Statins on Renal Function in Chronic Kidney Disease Patients |
title_full | Effect of Statins on Renal Function in Chronic Kidney Disease Patients |
title_fullStr | Effect of Statins on Renal Function in Chronic Kidney Disease Patients |
title_full_unstemmed | Effect of Statins on Renal Function in Chronic Kidney Disease Patients |
title_short | Effect of Statins on Renal Function in Chronic Kidney Disease Patients |
title_sort | effect of statins on renal function in chronic kidney disease patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215008/ https://www.ncbi.nlm.nih.gov/pubmed/30390007 http://dx.doi.org/10.1038/s41598-018-34632-z |
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