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Linkage analysis of multiplex Caribbean Hispanic families loaded for unexplained early-onset cases identifies novel Alzheimer's disease loci

INTRODUCTION: Less than 10% of early-onset Alzheimer's disease (EOAD) is explained by known mutations. METHODS: We conducted genetic linkage analysis of 68 well-phenotyped Caribbean Hispanic families without clear inheritance patterns or mutations in APP, PSEN1, and PSEN2 and with two or more i...

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Detalles Bibliográficos
Autores principales:	Cheng, Rong, Tang, Min, Martinez, Izri, Ayodele, Temitope, Baez, Penelope, Reyes-Dumeyer, Dolly, Lantigua, Rafael, Medrano, Martin, Jimenez-Velazquez, Ivonne, Lee, Joseph H., Beecham, Gary W., Reitz, Christiane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215058/ https://www.ncbi.nlm.nih.gov/pubmed/30406174 http://dx.doi.org/10.1016/j.dadm.2018.07.007

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